Pain education program for chronic musculoskeletal pain

Keeping It Simple Study (KISS) - Pain Science Education for Patients With Chronic Musculoskeletal Pain Undergoing Community-based Rehabilitation: A Multicenter Randomized Controlled Trial

Not applicable Interventional Aalborg University · NCT06297447

This study tests if a new pain education program can help adults with long-lasting musculoskeletal pain manage their pain better and improve their quality of life.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment200 (estimated)
Ages18 Years and up
SexAll
SponsorAalborg University Academic / other
Locations3 sites (Holbæk, Region Sjælland and 2 other locations)
Trial IDNCT06297447 on ClinicalTrials.gov

What this trial studies

The KISS project aims to evaluate the effectiveness of a pain neuroscience education program (PNE4Adults) on rehabilitation outcomes for patients suffering from chronic musculoskeletal pain. This program addresses maladaptive beliefs and psychological factors associated with chronic pain, which can hinder recovery. By combining pain science education with usual care, the study seeks to improve patients' pain management, self-efficacy, and overall quality of life. The study is conducted in specific municipalities in Denmark, targeting adults with chronic pain lasting more than three months.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with chronic musculoskeletal pain referred for rehabilitation in specific municipalities in Denmark.

Not a fit: Patients with cognitive deficits, serious pathologies, or those unable to cooperate may not benefit from this program.

Why it matters

Potential benefit: If successful, this program could significantly improve pain management and quality of life for patients with chronic musculoskeletal pain.

How similar studies have performed: Previous studies have shown that pain science education can lead to meaningful improvements in pain management and rehabilitation outcomes, indicating a promising approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients referred for rehabilitation in the municipalities Køge, Holbæk, and Solrød
* With chronic (\>3 months) musculoskeletal pain.
* Adult patients (≥18 years) - no upper limit
* Able to understand, speak, and write Danish.

Exclusion Criteria:

* Known cognitive deficits (e.g., dementia).
* Diagnosed with cancer or other serious pathologies, e.g., cauda equina.
* Pregnancy
* Drug addiction defined as the use of cannabis, opioids, or other drugs.
* Neurologic or psychiatric diagnoses that hinder participation, e.g., stroke and borderline.
* Lack of ability to cooperate.

Where this trial is running

Holbæk, Region Sjælland and 2 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Musculoskeletal PainChronic PainPain educationChronic painPNE4AdultsAdultsRehabilitationHealth literacy
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.