Biopsychosocial Intergenerational Factors in Pediatric Amplified Musculoskeletal Pain
Official title: Biopsychosocial Intergenerational Risk and Resilience Factors in Pediatric Amplified Musculoskeletal Pain
Funded at Boston Children's Hospital · NIH-11293093 · Data updated 2026-11-12
A study in children with amplified musculoskeletal pain and their mothers aims to understand how stress, psychology, and family factors influence the development and persistence of the pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $756,375 |
| NIH project number | 1R01AR085552-01A1 |
| Project ID | NIH-11293093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and youths with Amplified Musculoskeletal Pain Syndrome and their birth parent(s) who are willing to participate.
✕Less likely to help
Some families may not benefit if the pain is not primarily influenced by the studied intergenerational factors or if participation is not feasible.
What this research studies
This project looks at how biological, psychological, and social factors across both a child with chronic pain and their birth parent influence AMPS. Researchers will collect data from pediatric patients and their mothers to explore stress physiology, adverse experiences, and family dynamics. The goal is to identify intergenerational patterns that could inform new prevention and treatment approaches, with a focus on real-world applicability for families affected by AMPS.
Why it matters
Potential benefit: If successful, findings could lead to more effective, family-informed prevention and treatment strategies for AMPS.
How similar studies have gone: Previous work suggests intergenerational factors play a role in chronic pain, but this study aims to test a comprehensive biopsychosocial intergenerational model.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Nelson, Sarah Mary — Boston Children's Hospital
- Study coordinator: Nelson, Sarah Mary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.