Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Evaluating new methods for staging and prognosis in malignant pleural mesothelioma

Official title: Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

Run by Dana-Farber Cancer Institute · NCT03683680 · Data updated 2026-11-12

This study is testing a new way to better understand the stage and outlook of malignant pleural mesothelioma by looking at tissue samples from patients to help doctors make more informed treatment decisions.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment240 (estimated)
SponsorDana-Farber Cancer Institute
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedOctober 31, 2018
Main results expectedJanuary 1, 2030
Study endsOctober 1, 2030
Registry record updatedMay 5, 2026
Trial IDNCT03683680 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adult patients aged 18 and older diagnosed with malignant pleural mesothelioma who are undergoing diagnostic pleural biopsy or related procedures.

Probably not a fit

Patients who are unsuitable for surgery, treatment, or diagnosis will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research evaluates a novel approach to determine the stage and prognosis of patients with malignant pleural mesothelioma. By collecting pleural biopsies during routine diagnostic procedures, the study aims to analyze tissue characteristics that could enhance the accuracy of cancer staging and prognosis estimation prior to surgical intervention. The goal is to improve clinical decision-making and patient outcomes through better classification of cancer severity.

Why it matters

Potential benefit: If successful, this study could lead to more accurate staging and prognosis for patients with malignant pleural mesothelioma, potentially improving treatment planning.

How similar studies have gone: While there have been studies on mesothelioma prognosis, this specific approach using pleural biopsies for staging is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All adult patients with a diagnosis of malignant pleural mesothelioma undergoing

  * diagnostic pleural biopsy
  * pleuroscopy
  * and/or VATS resections
* Participants must be 18 years of age or older.

Exclusion Criteria:

-Any patient who is found to be unsuitable for

* surgery,
* treatment
* diagnosis,

Where it's running

  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

  • Principal investigator: Raphael Bueno, MD — Brigham and Women's Hospital
  • Study coordinator: Raphael Bueno, MD
  • Email: rbueno@partners.org
  • Phone: 617-732-5690

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.