Targeting a specific tumor marker for imaging and treatment of mesothelioma
Official title: Targeting tumor-specific epitope for imaging and therapy for mesothelioma
Funded at University of Virginia · NIH-11057986 · Data updated 2026-11-12
This study is testing a new way to use targeted radiation therapy to treat the tough-to-treat sarcomatoid subtype of malignant mesothelioma, aiming to provide patients with a more effective and precise treatment that focuses on the tumor while protecting healthy tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $696,447 |
| NIH project number | 1R01CA288612-01A1 |
| Project ID | NIH-11057986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with malignant mesothelioma, particularly those with the sarcomatoid subtype.
✕Less likely to help
Patients with other types of cancer or those without mesothelioma may not receive any benefit from this research.
What this research studies
This research focuses on developing a new imaging and therapy approach for malignant mesothelioma, particularly the difficult-to-treat sarcomatoid subtype. It utilizes a targeted alpha therapy method that employs a specific antibody to deliver potent radiation directly to the tumor cells while minimizing damage to surrounding healthy tissues. The study aims to evaluate the effectiveness of a novel isotope pair for imaging and treatment, which has shown promise in preliminary tests. Patients may benefit from a more precise and effective treatment option tailored to their specific tumor characteristics.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for patients with mesothelioma, potentially improving survival rates and quality of life.
How similar studies have gone: Other research has shown success with similar targeted therapies in different cancers, indicating potential for this novel approach in mesothelioma.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: He, Jiang — University of Virginia
- Study coordinator: He, Jiang
Related research
Other NIH-funded projects on the same topics.
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Tumor-targeted imaging and alpha-particle therapy for mesothelioma
This project develops an antibody-based imaging approach and a targeted alpha-particle therapy to find and kill mesothelioma tumors, including hard-to-treat sarcomatoid cases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.