Understanding visual learning and plasticity in macular degeneration
Characterization of Multiple Factors in Training and Plasticity in Central Vision Loss: Macular Degeneration
This study is testing if training can help people with macular degeneration improve their everyday vision by understanding how their brains adapt to changes in sight.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT05454124 on ClinicalTrials.gov |
What this trial studies
This study investigates how perceptual learning can improve daily visual tasks for individuals with central vision loss due to macular degeneration. By simulating central vision loss in normally seeing individuals, researchers aim to understand how changes in visual experience affect brain activity and connectivity. The study employs eye-trackers and gaze-contingent displays to analyze the development of peripheral looking patterns. The ultimate goal is to inform new therapies that enhance visual performance in patients suffering from low vision.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-89 with severely impaired vision (20/100 or worse) due to macular degeneration.
Not a fit: Patients with conditions such as claustrophobia, certain metal implants, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve the quality of life for individuals with macular degeneration.
How similar studies have performed: Other studies have shown promise in using perceptual learning approaches for visual rehabilitation, indicating potential success for this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18-89 * Severely impaired vision in both eyes (20/100 or worse) * diagnosis of Macular Degeneration by an Ophthalmologist * Light sensitivity in the macular retina that is at least 10 dB units worse than in peripheral regions, as demonstrated by a scanning laser ophthalmoscope (MAIA) * Medical record review indicating this level of disease severity has been present for at least 2 years * Reside within 50 miles of study site Exclusion Criteria: * Pacemaker or any ferromagnetic metal implanted in their body * Metal of any type implanted in their head (limited dental work is acceptable) * Claustrophobia * Being hearing-impaired * Weight over 300 pounds * Maximum body girth over 60 inches * Previous serious head injury * Presence of hallucinations or delusions * Excessive old, or colorful tattoos, especially near the head * Pregnancy * Braces/permanent retainer
Where this trial is running
Birmingham, Alabama
- UAB — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Study coordinator: Rachel A Chua, MS
- Email: r2chel@uab.edu
- Phone: 205-410-4041
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.