Improving Immunotherapy for Lung Cancer with CT Scans
Predictive and Diagnostic Radiomic Signatures in Non-Small Cell Lung Cancer (NSCLC)on Immunotherapy
This work aims to find new ways to predict which non-small cell lung cancer patients will respond best to immunotherapy using information from their routine CT scans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11193547 on NIH RePORTER |
What this research studies
We are looking at detailed information from CT scans, called 'radiomic features,' to understand more about lung tumors. These features can show us things like blood vessel patterns and how immune cells are interacting with the tumor, which are important for how immunotherapy works. By combining this CT scan information with existing markers, we hope to create a more accurate way to choose the right immunotherapy for each patient. This could help more patients get effective treatment and avoid therapies that won't work for them.
Who could benefit from this research
Good fit: This research is relevant for patients with non-small cell lung cancer who are considering or undergoing immunotherapy.
Not a fit: Patients without non-small cell lung cancer or those not receiving immunotherapy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors better select which non-small cell lung cancer patients will benefit from specific immunotherapy treatments, potentially improving outcomes and avoiding unnecessary side effects.
How similar studies have performed: Early findings, including preliminary data from this team, suggest that CT scan features can provide valuable insights into tumor characteristics relevant to immunotherapy, though this specific approach is still being fully explored.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kontos, Despina — Columbia University Health Sciences
- Study coordinator: Kontos, Despina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.