Investigating how non-small cell lung cancer interacts with the immune system using humanized mouse models.
Official title: Autologous Humanized Mouse Model of Non-Small Cell Lung Cancer (NSCLC) to Investigate the Tumor-Immune Landscape and Its Response to Treatment
Funded at Yale University · NIH-10683397 · Data updated 2026-11-12
This study is looking at how non-small cell lung cancer interacts with the immune system using special mice that have a human-like immune system, to help understand why some patients respond well to treatments while others don’t.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 17, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $148,177 |
| NIH project number | 5K08CA245211-05 |
| Project ID | NIH-10683397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-small cell lung cancer who are undergoing treatment.
✕Less likely to help
Patients with other types of lung cancer or those who are not eligible for treatment may not benefit from this research.
What this research studies
This research focuses on understanding non-small cell lung cancer (NSCLC) and its interaction with the immune system. By creating a humanized mouse model that mimics the patient's own immune system and tumor, researchers aim to study how the tumor microenvironment affects treatment responses. The approach includes advanced techniques like flow cytometry and genomic analysis to identify specific immune cell populations and their roles in tumor growth. This detailed investigation could reveal why some patients respond to treatments while others do not.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for NSCLC patients by identifying new therapeutic targets.
How similar studies have gone: Previous research has shown promise in using humanized models to study cancer-immune interactions, suggesting this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Chiorazzi, Michael — Yale University
- Study coordinator: Chiorazzi, Michael
Related research
Other NIH-funded projects on the same topics.
-
How air pollution and neighborhood stress affect lung tumors in African American patients
This project looks at whether long-term air pollution and neighborhood disadvantage change tumor DNA and short-term recurrence risk in early-stage lung cancer among African American patients.
-
Improving Immunotherapy for Lung Cancer with CT Scans
This work aims to find new ways to predict which non-small cell lung cancer patients will respond best to immunotherapy using information from their routine CT scans.
-
Targeting EGFR‑mutant lung cancer cells that resist targeted drugs
This project tests lab and translational approaches to eliminate EGFR‑mutant lung cancer cells that survive targeted drugs, for people with EGFR‑positive non‑small cell lung cancer.
-
Targeting resistant cells in lung cancer treatment
This study is looking at why some lung cancer cells don't respond to certain treatments and aims to find new ways to help patients get better by targeting those stubborn cells, which could lead to longer-lasting results.
-
ABL kinase signaling and DNA collisions in small cell lung cancer
A drug target study in small cell lung cancer explores how blocking ABL kinase affects conflicts between transcription and DNA replication, which could influence tumor growth and survival.
-
XRN1 as a potential therapy target in lung cancer
A scientist-led program will study a cellular gene called XRN1 to see if turning it off can help treat non-small cell lung cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.