Investigating how non-small cell lung cancer interacts with the immune system using humanized mouse models.
Autologous Humanized Mouse Model of Non-Small Cell Lung Cancer (NSCLC) to Investigate the Tumor-Immune Landscape and Its Response to Treatment
This study is looking at how non-small cell lung cancer interacts with the immune system using special mice that have a human-like immune system, to help understand why some patients respond well to treatments while others don’t.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10683397 on NIH RePORTER |
What this research studies
This research focuses on understanding non-small cell lung cancer (NSCLC) and its interaction with the immune system. By creating a humanized mouse model that mimics the patient's own immune system and tumor, researchers aim to study how the tumor microenvironment affects treatment responses. The approach includes advanced techniques like flow cytometry and genomic analysis to identify specific immune cell populations and their roles in tumor growth. This detailed investigation could reveal why some patients respond to treatments while others do not.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-small cell lung cancer who are undergoing treatment.
Not a fit: Patients with other types of lung cancer or those who are not eligible for treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for NSCLC patients by identifying new therapeutic targets.
How similar studies have performed: Previous research has shown promise in using humanized models to study cancer-immune interactions, suggesting this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Chiorazzi, Michael — Yale University
- Study coordinator: Chiorazzi, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.