Cryobiopsy for lung cancer lymph nodes
Official title: Transbronchial EBUS-guided TBNA and Cryobiopsy of Mediastinal Lymph Nodes in Patients Nonsuspicious for Lung Cancer, Using Different Cryoprobe Freezing Times
Run by University of Zurich · NCT06921681 · Data updated 2026-11-12
This study is testing a new way to take tissue samples from lymph nodes in lung cancer patients using freezing techniques to see if it gives better results than the usual methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 136 (estimated) |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Basel) |
| Status | Recruiting |
| Started | March 7, 2025 |
| Main results expected | April 1, 2029 |
| Study ends | December 31, 2029 |
| Registry record updated | April 10, 2025 |
| Trial ID | NCT06921681 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 90 with mediastinal or hilar lesions requiring diagnostic bronchoscopy.
✕Probably not a fit
Patients with contraindications to bronchoscopy or those with certain blood disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of ultrasound-guided cryobiopsy for obtaining tissue samples from mediastinal and hilar lymph nodes in patients with lung cancer. It aims to determine the optimal freezing times and number of biopsies needed to maximize diagnostic yield compared to traditional methods. Participants will undergo cryobiopsy procedures with varying freezing durations to assess the quality of tissue samples for histological analysis. The study seeks to improve diagnostic accuracy and inform targeted therapies for lung malignancies.
Why it matters
Potential benefit: If successful, this approach could enhance the accuracy of lung cancer diagnoses and improve treatment options for patients.
How similar studies have gone: Previous studies have indicated that cryobiopsy can yield better diagnostic results than traditional methods, suggesting a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least one mediastinal lesion or hilar 1 cm or longer in the short axis requiring diagnostic bronchoscopy * Age between 18 and 90 years * Written informed consent after participant's information Exclusion Criteria: * Age \< 18 and \> 90 years * Lacking ability to form an informed consent (including impaired judgement, communication barriers) * Contraindication against bronchoscopy (e.g. co-morbidities) * Mediastinal abscess or cyst * Extraordinary blood supply of the lesion visualized by EBUS bronchoscope * INR \> 1.5 or Thrombocytes \< 100 G/l * Clopidogrel or other new antiplatelet drugs within 7 days before biopsy (salicylic acid alone allowed) * Anticoagulation with NOAC within 48 hours before biopsy * Pulmonary lesions suspicious of lung carcinoma
Where it's running
-
Jürgen Hetzel
Basel, Switzerland Recruiting
Study contacts
- Study coordinator: Carolin Steinack
- Email: carolin.steinack@usz.ch
- Phone: 0041 44 255 8689
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.