Evaluating neoadjuvant immunotherapy for lung cancer treatment outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter retrospective real-world study aims to assess the safety, efficacy, and survival outcomes of neoadjuvant immunotherapy in patients with non-small cell lung cancer (NSCLC). It encompasses various treatment pathways, including surgery and radiotherapy, to provide comprehensive real-world evidence that addresses existing gaps in clinical trials. By establishing a cohort that spans from the neoadjuvant therapy period to follow-up, the study seeks to inform treatment decisions for both operable and inoperable cases of lung cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Histologically confirmed non-small cell lung cancer (NSCLC), regardless of the presence of EGFR or ALK sensitive driver gene mutations;
2. Clinical staging of IA-IIIC according to the AJCC 8th Edition before neoadjuvant treatment;
3. Received at least one cycle of neoadjuvant immunotherapy (with or without chemotherapy);
4. Assessed as resectable or potentially resectable by surgical experts prior to treatment.

Exclusion Criteria:

1. Confirmed M1 disease;
2. History of previous lung malignancy or other metastatic malignant tumors;
3. Participation in other randomized controlled trials involving neoadjuvant treatment;
4. Significant missing clinical data.

Where it's running

• Peking University Cancer Hospital & Institute
  Beijing, Beijing Municipality, China Recruiting
• Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting
• Inner Mongolia Hospital of Peking University Cancer Hospital
  Hohhot, Inner Mongolia, China Recruiting
• The Third Affliated Hospital of Kunming Medical University
  Kunming, Yunnan, China Recruiting

Study contacts

• Study coordinator: Nan Wu, MD
• Email: nanwu@bjmu.edu.cn
• Phone: 0086-10-88196569

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.