Condition

Leptomeningeal Metastasis clinical trials and research

• 19Clinical trials
• 3NIH research projects
• 8Countries

Newest Leptomeningeal Metastasis clinical trials

All recruiting trials (19)

• Brain-avoiding proton craniospinal irradiation for leptomeningeal metastases

  This study tests BRAVO pCSI, a proton therapy approach that avoids certain brain regions, to see if it helps adults with leptomeningeal metastases from solid tumors.

  Recruiting University of Miami · Miami, Florida · NCT07789912

• Double-dose third-generation EGFR-TKI with bevacizumab and intrathecal chemotherapy for leptomeningeal NSCLC

  This trial will try whether giving a double dose of a third-generation EGFR-TKI together with bevacizumab and spinal (intrathecal) chemotherapy can help people with EGFR-mutant NSCLC whose leptomeningeal metastasis progressed after a standard-dose third-generation EGFR-TKI.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jiangxi · NCT07398599

• Pulsatile high-dose furmonertinib for EGFR-mutant NSCLC with leptomeningeal metastasis

  This tests whether taking high-dose furmonertinib every other day helps people with EGFR-mutant non-small cell lung cancer that has spread to the leptomeninges.

  Recruiting Guangzhou University of Traditional Chinese Medicine · Guangzhou, Guangdong · NCT07348965

• Multiple intraventricular doses of rhenium‑186 nanoliposome for leptomeningeal metastases

  This trial will test whether giving multiple intraventricular doses of a rhenium‑186 nanoliposome is safe and could help adults with leptomeningeal metastases from solid tumors.

  Recruiting Phase 1/2 Cerenome · San Antonio, Texas · NCT07098806

• High-dose firmonertinib plus chemotherapy injected into the spinal fluid for EGFR-mutant NSCLC with leptomeningeal spread

  This tests whether high-dose firmonertinib combined with chemotherapy injected into the spinal fluid helps people with EGFR-mutant non-small cell lung cancer that has spread to the leptomeninges.

  Recruiting Phase 4 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07092202

• Treatment of refractory non-squamous non-small cell lung cancer with leptomeningeal metastases using Pemetrexed and Nivolumab injections

  This study is testing if a combination of Pemetrexed and Nivolumab injections can help people with tough-to-treat lung cancer that has spread to the protective layers around the brain.

  Recruiting Phase 2 Shanghai Cancer Hospital, China · Shanghai, Shanghai Municipality · NCT06901817

• Treatment for leptomeningeal metastasis using a bispecific antibody and chemotherapy

  This study is testing a new treatment that combines a special antibody and chemotherapy to see if it can help people with leptomeningeal metastasis feel better and live longer.

  Recruiting Phase 1/2 Guangzhou Medical University · Huizhou, Guangdong · NCT06809517

• Intrathecal treatment for lung cancer with leptomeningeal metastases

  This study is testing a new way to deliver two cancer drugs directly into the spine to see if it helps people with lung cancer that has spread to the brain and who haven't responded well to other treatments.

  Recruiting Phase 1 Shanghai Chest Hospital · Shanghai · NCT06663306

• Combining low dose brain radiotherapy with immunotherapy and intrathecal chemotherapy for lung cancer

  This study is testing a new treatment that combines low dose brain radiation, immune therapy, and chemotherapy to see if it helps people with tough lung cancer that has spread to the brain.

  Recruiting Phase 1 Sichuan University · Chengdu, Sichuan · NCT06431685

• Assessment of patients with leptomeningeal metastasis

  This study is trying to create a standard way to check how patients with leptomeningeal metastases are doing, so doctors can better understand and manage their condition.

  Recruiting at 3 sites University of Zurich · Houston, Texas and 2 other locations · NCT06417710

• Using Pemetrexed via Ommaya Reservoir for Lung Cancer with Leptomeningeal Metastasis

  This study is testing a new way to give a lung cancer drug directly to the brain to see if it helps people with cancer that has spread to the brain after other treatments didn't work.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT06399926

• Comparing intra-pemetrexed with osimertinib for treating leptomeningeal metastasis in lung cancer

  This study is testing whether combining a specific type of chemotherapy with a targeted lung cancer drug can help people with leptomeningeal metastasis from lung cancer feel better compared to using the targeted drug alone.

  Recruiting Guangzhou Medical University · Huizhou, Guangdong · NCT06304441

• Intrathecal pemetrexed for leptomeningeal metastases after osimertinib in lung adenocarcinoma

  This trial will try giving pemetrexed directly into the spinal fluid to treat leptomeningeal metastases in people with EGFR‑mutant lung adenocarcinoma whose cancer progressed after double‑dose osimertinib.

  Recruiting Phase 2 Guangzhou Medical University · Huizhou, Guangdong · NCT06296745

• Intrathecal chemotherapy for HER2-negative breast cancer with leptomeningeal metastasis

  This study is testing whether a special type of chemotherapy delivered directly to the spinal fluid can help people with HER2-negative breast cancer that has spread to the brain's protective layers feel better compared to just using regular chemotherapy.

  Recruiting Phase 4 Fudan University · Shanghai, Shanghai Municipality · NCT06230055

• Using Trastuzumab Deruxtecan to treat brain cancer

  This study is testing if a new drug called trastuzumab deruxtecan can effectively treat brain cancer in adults with specific types of tumors that have the HER2 protein.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT06058988

• Pemetrexed injected into the spinal fluid for EGFR‑mutant lung cancer that has spread to the leptomeninges.

  This tests whether giving pemetrexed directly into the spinal fluid helps people with EGFR‑mutant non‑small cell lung cancer whose cancer has spread to the leptomeninges after osimertinib has stopped working.

  Recruiting Phase 2 Taipei Veterans General Hospital, Taiwan · Taipei, Taiwan · NCT05805631

• Treatment for breast cancer patients with leptomeningeal disease

  This study is testing a new treatment combining tucatinib, capecitabine, and intrathecal trastuzumab to see if it can help people with HER2-positive metastatic breast cancer and leptomeningeal disease live longer.

  Recruiting at 10 sites Phase 2 Unicancer · Bordeaux and 10 other locations · NCT05800275

• Proton therapy for leptomeningeal metastasis treatment

  This study is testing if proton therapy can help people with leptomeningeal metastasis, a serious cancer complication, feel better and manage their symptoms.

  Recruiting at 2 sites University of Aarhus · Aarhus, Aarhus and 1 other locations · NCT05746754

• Analyzing spinal fluid in lung cancer patients with leptomeningeal disease

  This study is trying to see how the spinal fluid and blood of lung cancer patients with a specific mutation differ, to better understand their condition and how it affects their quality of life.

  Recruiting British Columbia Cancer Agency · Vancouver, British Columbia · NCT05257967

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrin alpha-6 drives breast cancer spread to the brain’s protective membranes

  This project tests how blocking integrin a6 may stop breast cancer cells from spreading to the brain’s protective membranes and thriving there.

  NIH research Duke University · Durham, United States · NIH-11389659

• Targeting the spread of brain tumors in children

  This study is exploring a new way to treat medulloblastoma, a common brain tumor in kids, by using tiny particles to deliver a special antibiotic directly to the tumor, which could make the treatment work better and cause fewer side effects for young patients.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-10907839

• Investigating a new way to target cancer spread in the brain's protective layers

  This study is looking at how certain leukemia cells can sneak into the brain and spread, with the goal of finding new ways to stop this from happening and help patients with blood cancers and other tumors that affect the brain.

  NIH research Duke University · Durham, United States · NIH-10755687

Related topics

Quick answers

How many Leptomeningeal Metastasis clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in China (11 trials), United States (4 trials), France (1 trial), Taiwan (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 2, Phase 1: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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