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Colorectal Cancer Metastatic clinical trials and research

• 46Clinical trials
• 14Countries

Newest Colorectal Cancer Metastatic clinical trials

All recruiting trials (46)

• Metastatic liver cancer patient registry from multiple Chinese centers

  This is a registry that collects real-world data on adults with liver metastases to understand patterns and prognosis and to support future research.

  Recruiting at 2 sites Anhui Provincial Hospital · Bengbu, Anhui and 2 other locations · NCT07602504

• Combination of balstilimab, botensilimab, and agenT-797 in pMMR colorectal cancer with liver metastases

  This trial tests whether a three-drug combination can help adults with metastatic, MSS colorectal cancer that has spread to the liver.

  Recruiting Phase 2 Scripps Health · La Jolla, California · NCT07550088

• Dual-target CAR-NK therapy for advanced colorectal cancer with CEA, GUCY2C, or HER2 markers

  This trial tests an off-the-shelf CAR-NK cell treatment that targets two tumor markers to see if it can shrink tumors in adults with advanced or metastatic colorectal cancer whose tumors express those markers.

  Recruiting Phase 1/2 Beijing Biotech · Shenzhen, Guangdong · NCT07462650

• COLONYVAQ™: personalized quantum‑classical neoantigen peptide vaccine combined with chemotherapy and nivolumab for MSS stage III colorectal cancer

  This trial will test a personalized neoantigen peptide vaccine guided by quantum‑classical AI together with standard oxaliplatin‑based chemotherapy and nivolumab in patients with completely resected, microsatellite‑stable stage III colorectal cancer.

  Recruiting Early Phase 1 Biogenea Pharmaceuticals Ltd. · Thessaloniki · NCT07328087

• ABT-301 with tislelizumab and bevacizumab for pMMR/non‑MSI‑H advanced or metastatic colorectal cancer

  This trial will test whether adding the oral drug ABT-301 to fixed-dose tislelizumab and bevacizumab is safe and tolerable for adults with pMMR/non‑MSI‑H locally advanced or metastatic colorectal cancer who have had at least two prior systemic therapies.

  Recruiting Phase 1/2 Anbogen Therapeutics, Inc. · Liverpool, New South Wales and 14 other locations · NCT07244705

• Second-line regorafenib for advanced RAS-mutant colorectal cancer

  This trial will test whether regorafenib given as a less-intensive, personalized second-line option can preserve quality of life and extend survival for people with RAS‑mutant metastatic colorectal cancer who had a long first-line benefit or have only one metastatic site.

  Recruiting Phase 2 National Cancer Institute, Naples · Naples, Italy · NCT07213570

• Hybrid hospital and community delivery of hepatic artery infusion chemotherapy for liver metastases and intrahepatic cholangiocarcinoma

  This Phase 2 trial will test whether giving floxuridine through a surgically implanted hepatic artery infusion pump — with follow-up care either at a major hospital or by local community oncologists — is safe and practical for adults with colorectal cancer liver metastases or unresectable intrahepatic cholangiocarcinom

  Recruiting Phase 2 University of Kentucky · Lexington, Kentucky · NCT07201519

• Implantable microdevice to test drug effects inside colorectal liver tumors

  This will try placing a tiny implant into liver metastases to see if different cancer drugs diffuse into and affect the tumor tissue in adults scheduled for surgery for colorectal cancer spread to the liver.

  Recruiting at 2 sites Early Phase 1 Northwell Health · Lake Success, New York and 1 other locations · NCT07193862

• Nelitolimod immunotherapy given to the liver before planned removal of colorectal cancer metastases

  This will test whether giving nelitolimod directly into the liver before surgery can boost the immune response against colorectal cancer that has spread to the liver.

  Recruiting Early Phase 1 Northwell Health · Lake Success, New York · NCT07172282

• Intravenous HNF4α srRNA (CD-GA-102) for unresectable or metastatic colorectal cancer

  This trial will try IV CD-GA-102 (HNF4α srRNA) alone or with other cancer medicines to see if it is safe and can help adults with unresectable or metastatic colorectal cancer who have progressed on or cannot tolerate standard treatments.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai, None Selected · NCT07050394

• Irinotecan liposome combined with cetuximab and bevacizumab for irinotecan-resistant metastatic colorectal cancer

  This trial will test whether combining irinotecan liposomes with cetuximab and bevacizumab can shrink tumors or slow growth in people with metastatic colorectal cancer that no longer responds to irinotecan.

  Recruiting Phase 2 Chinese PLA General Hospital · Beijing · NCT07044921

• ctDNA-guided choice of cetuximab versus bevacizumab with trifluridine/tipiracil for RAS/BRAF wild-type metastatic colorectal cancer

  This trial tests whether a ctDNA blood test can help choose cetuximab plus trifluridine/tipiracil versus bevacizumab plus trifluridine/tipiracil for people with RAS/BRAF wild-type metastatic colorectal cancer who have progressed after prior treatments.

  Recruiting Phase 1/2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07012954

• Blood ctDNA monitoring for hepatocellular carcinoma and colorectal cancer that spread to the liver

  This trial tests whether a blood test that detects circulating tumor DNA (ctDNA) can track recurrence or progression in adults undergoing liver surgery or transplant for HCC or colorectal cancer with liver-only metastases.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT07001085

• Comparing two treatments for advanced colorectal cancer

  This study is testing whether a combination of two cancer treatments works better than another combination for people with advanced colorectal cancer that hasn’t responded to other therapies.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06992648

• Combining multimodal tumor ablation with immunotherapy for liver metastases

  This trial will test whether adding the immunotherapy drug pucotenlimab to multimodal thermal ablation helps people with liver metastases from colorectal cancer, triple-negative breast cancer, or melanoma.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06889610

• Testing a new stool test for colorectal cancer detection

  This study is testing a new stool test to see if it can help find colorectal cancer and advanced growths in people aged 45 and older who are at average risk.

  Recruiting Mainz Biomed · Morrisville, North Carolina · NCT06864338

• Oral trifluridine/tipiracil with bevacizumab and sintilimab, with or without targeted radiation, for advanced MSS/pMMR colorectal cancer after two or more prior treatments

  This trial will try oral trifluridine/tipiracil combined with bevacizumab and sintilimab, with or without focused radiation, in people with advanced MSS/pMMR colorectal cancer who have progressed after at least two prior therapies.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06764680

• Combining irinotecan liposomes with cetuximab and vermofenib for advanced colorectal cancer

  This study is testing if a new combination of treatments can help patients with advanced colorectal cancer, who haven't responded to previous therapies, feel better and have better outcomes.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06763029

• Adding valproic acid to panitumumab and irinotecan for metastatic colorectal cancer rechallenge

  This trial tests whether giving oral valproic acid along with panitumumab and irinotecan helps people with RAS/BRAF wild-type metastatic colorectal cancer who are being rechallenged with anti‑EGFR therapy.

  Recruiting at 3 sites Phase 2 National Cancer Institute, Naples · Caserta, CE and 7 other locations · NCT06714357

• Comparing liver transplant methods for colorectal cancer patients

  This study is testing different liver transplant methods for colorectal cancer patients to see which one helps them recover faster and live longer after the surgery.

  Recruiting Northwestern University · Chicago, Illinois · NCT06698146

• Combining Fruquintinib, Chidamide, and Sintilimab for Advanced Colorectal Cancer Treatment

  This study is testing a new combination of three drugs to see if it can help people with advanced colorectal cancer that hasn't improved with other treatments.

  Recruiting Phase 2 Chinese PLA General Hospital · Beijing · NCT06685276

• Testing a new immunotherapy for advanced colorectal cancer

  This study is testing a new immunotherapy treatment for patients with advanced colorectal cancer to see if a combination of two drugs can help those whose cancer hasn't responded to standard treatments.

  Recruiting at 3 sites Phase 2 Buzzard Pharmaceuticals · Los Angeles, California and 2 other locations · NCT06634875

• Using medical cannabis to relieve symptoms in patients with advanced pancreatic cancer

  This study is testing if medical cannabis can help relieve symptoms like pain and nausea in people with advanced pancreatic cancer.

  Recruiting Phase 2 HealthPartners Institute · Saint Louis Park, Minnesota · NCT06605430

• TL938 plus trastuzumab for HER2-positive metastatic colorectal cancer

  This Phase 2 test checks whether combining oral TL938 with trastuzumab helps adults with HER2-positive, RAS wild-type metastatic or unresectable colorectal cancer that has progressed after standard chemotherapy.

  Recruiting Phase 2 Suzhou Teligene Ltd. · Beijing, Beijing Municipality · NCT06589830

• Combining DEBIRI with chemotherapy for colorectal cancer liver metastases

  This study is testing if adding a special treatment called DEBIRI to regular chemotherapy can help patients with colorectal cancer that has spread to the liver feel better and possibly have surgery later.

  Recruiting Phase 3 Tehran University of Medical Sciences · Tehran, Tehran Province · NCT06555003

• Combining cetuximab, irinotecan, and a PD-1 inhibitor for treating specific colorectal cancer

  This study is testing a new combination of treatments for patients with hard-to-treat right-sided colorectal cancer to see if it can help them when other options haven't worked.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06547203

• Second-line treatment for advanced colorectal cancer using new chemotherapy options

  This study is testing a new combination of chemotherapy drugs to see if it can help people with advanced colorectal cancer who haven't had success with their first treatment.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06540326

• Combination immunotherapy and chemotherapy for advanced colorectal cancer

  This study is testing a new treatment for patients with advanced colorectal cancer that combines immunotherapy and chemotherapy to see if it can help them better than current options.

  Recruiting Phase 2 Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS · Meldola, Forlì Cesena and 1 other locations · NCT06522919

• Combining Regorafenib, Sintilimab, and Electroacupuncture for Advanced Colorectal Cancer

  This study is testing a new treatment plan that combines two medications and electroacupuncture to see if it helps people with advanced colorectal cancer who haven't had success with previous chemotherapy.

  Recruiting The First People's Hospital of Changzhou · Changzhou · NCT06456515

• Investigating genetic similarities between primary colorectal tumors and their brain metastases

  This study is looking at the genetic similarities between original colorectal cancer tumors and their brain metastases to see how closely they match in terms of important gene mutations.

  Recruiting Blokhin's Russian Cancer Research Center · Moscow, Moscow · NCT06449989

• Exploring treatment strategies for a specific type of metastatic colorectal cancer

  This study is testing if a blood test that looks for certain cancer markers can help doctors decide the best treatment for people with a specific type of metastatic colorectal cancer.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06440902

• Evaluating biomarkers for immunotherapy resistance in metastatic colorectal cancer

  This study is trying to find out which patients with advanced colorectal cancer might not respond to a specific immunotherapy treatment called pembrolizumab, to help doctors choose the best options for their care.

  Recruiting at 3 sites Federation Francophone de Cancerologie Digestive · Bayonne and 19 other locations · NCT06353854

• Testing immunotherapy combinations for colorectal cancer that has spread to the liver

  This study is testing different combinations of immunotherapy treatments for people with colorectal cancer that has spread to the liver to see if they can improve treatment results before surgery.

  Recruiting Phase 2 Weill Medical College of Cornell University · New York, New York · NCT06300463

• Combining chemotherapy and immunotherapy for advanced colorectal cancer treatment

  This study is testing a new combination of chemotherapy and immunotherapy to see if it helps people with advanced colorectal cancer live longer and feel better.

  Recruiting Phase 2 The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Jinhua, Zhejiang · NCT06282445

• Combining Tunlametinib and Vemurafenib for Advanced Colorectal Cancer

  This study is testing if combining two drugs, Tunlametinib and Vemurafenib, can help people with advanced colorectal cancer that has a specific mutation do better than standard chemotherapy.

  Recruiting Phase 3 Shanghai Kechow Pharma, Inc. · Beijing, Beijing Municipality · NCT06008119

• Modified early post-operative intraperitoneal chemotherapy for cancer treatment

  This study is testing a new way of giving chemotherapy right after surgery to see if it works better and is safer for people with cancer that has spread in the abdomen.

  Recruiting Phase 2 Ciusss de L'Est de l'Île de Montréal · Montreal, Quebec · NCT05913674

• CNA3103 CAR-T cell treatment for metastatic colorectal cancer

  This study is testing a new CAR-T cell treatment called CNA3103 to see if it can safely help people with advanced colorectal cancer.

  Recruiting Phase 1/2 Carina Biotech Limited · Adelaide, South Australia · NCT05759728

• Comparing two chemotherapy approaches for unresectable colorectal cancer with liver metastases

  This study is testing two different chemotherapy methods for patients with colorectal cancer that has spread to the liver to see which one helps them feel better and live longer.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT05727163

• Direct chemotherapy delivery to the lungs for colorectal cancer metastases

  This study is testing a new way to deliver chemotherapy directly to the lungs during surgery for people with colorectal cancer that has spread there, to see if it can target cancer cells better while causing fewer side effects.

  Recruiting Phase 1 University Health Network, Toronto · Toronto, Ontario · NCT05611034

• Characterizing colorectal cancer spread to the peritoneum

  This study is trying to understand how colorectal cancer spreads to the abdominal lining by looking at tumor cells from patients to see if certain genetic changes can help predict how well treatments will work.

  Recruiting The Christie NHS Foundation Trust · Manchester · NCT05513716

• Exploring biomarkers for prognosis in recurrent and metastatic colorectal cancer after surgery

  This study is trying to find specific markers in blood and tumor samples that can help predict how well patients with recurring or advanced colorectal cancer will do after surgery.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05501353

• Living donor liver transplant for patients with colorectal cancer spread to the liver

  This study is trying to see how well living donor liver transplants work for people with colorectal cancer that has spread to the liver by collecting information on their survival and recovery.

  Recruiting University of Rochester · Rochester, New York · NCT05248581

• Cryoablation with Sintilimab and Regorafenib for Liver Metastases from Colorectal Cancer

  This study is testing if combining a freezing treatment with two medications can help people with liver cancer from colorectal cancer who haven't responded to previous treatments.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05057052

• Evaluating the effects of radiation therapy on colorectal cancer patients with lung-limited metastases

  This study is testing if a special type of radiation therapy can help people with colorectal cancer that has spread to their lungs by looking at changes in their tumor DNA and genetics before and after treatment.

  Recruiting National Cancer Institute, Naples · Naples, NAPOLI · NCT04854213

• Examining gut microbiome changes in advanced colorectal cancer during chemotherapy

  This study looks at how chemotherapy changes the gut bacteria in people with advanced colorectal cancer to see if understanding these changes can help improve treatment outcomes.

  Recruiting at 10 sites University Medical Center Groningen · Assen and 9 other locations · NCT03941080

• Liver transplantation for patients with colorectal cancer liver metastases

  This study is testing a new approach that combines surgery and liver transplantation to see if it can help patients with colorectal cancer that has spread to the liver live longer compared to standard chemotherapy.

  Recruiting at 2 sites Jena University Hospital · Jena and 1 other locations · NCT03488953

Related topics

Quick answers

How many Colorectal Cancer Metastatic clinical trials are recruiting right now?

46, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in China (20 trials), United States (10 trials), Italy (4 trials), Australia (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 21, Phase 1/2: 4, Early Phase 1: 4, Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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