Condition

Hepatocellular Cancer clinical trials and research

• 11Clinical trials
• 5NIH research projects
• 10Countries

Newest Hepatocellular Cancer clinical trials

All recruiting trials (11)

• PF-08634404 alone or with ipilimumab for adults with advanced hepatocellular carcinoma not removable by surgery

  This tests PF-08634404 by itself and together with ipilimumab in adults whose hepatocellular carcinoma is advanced and cannot be removed surgically.

  Recruiting at 60 sites Phase 1/2 Pfizer · Irvine, California and 59 other locations · NCT07227012

• Assessing blood biomarkers and MRI for liver cancer patients undergoing radiation therapy

  This study is testing if using special MRI scans and blood tests can help doctors keep track of liver health in patients with liver cancer who are getting radiation therapy.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06899152

• Assessing the effects of ABBV-324 on liver and lung cancers

  This study is testing a new drug called ABBV-324 to see if it can help adults with advanced liver or lung cancer feel better when taken alone or with another medication.

  Recruiting at 21 sites Phase 1 AbbVie · Duarte, California and 21 other locations · NCT06858813

• Oral Alintegimod with Ipilimumab followed by Nivolumab for advanced cancer

  This study is testing if a new oral medication called Alintegimod, combined with two other cancer treatments, can help people with advanced solid tumors feel better and live longer.

  Recruiting at 4 sites Phase 1/2 7 Hills Pharma, LLC · Aurora, Colorado and 4 other locations · NCT06362369

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• GPC3 targeted CAR-T cell therapy for advanced liver cancer

  This study is testing a new immune therapy using modified T cells to see if it can help people with advanced liver cancer that has a specific marker called GPC3.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05003895

• Neoantigen vaccine combined with nivolumab for liver cancer treatment

  This study is testing a personalized vaccine combined with a cancer drug to see if it can help people with liver cancer stay cancer-free after surgery.

  Recruiting Phase 2 National Cancer Centre, Singapore · Singapore · NCT04912765

• Evaluating progastrin levels in cancer patients

  This study is testing if measuring progastrin levels in the blood can help predict how cancer will progress and respond to treatment in patients with different types of cancer.

  Recruiting at 17 sites Hospices Civils de Lyon · Bron and 16 other locations · NCT03787056

• Detection of tumor cells and DNA in blood, urine, and bone marrow

  This study is testing new ways to find cancer cells and DNA in the blood, urine, and bone marrow of people with solid tumors and those at high risk for lung cancer to help improve early detection and personalized treatments.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT03551951

• Evaluating Quality of Life After Radiation Therapy for Liver Cancer

  This study is trying to see how radiation therapy affects the quality of life for people with liver cancer over time.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT03253536

• Detection of tumor cells and DNA in blood, urine, and bone marrow of cancer patients

  This study is testing if collecting and analyzing tumor cells and DNA from the blood, urine, and bone marrow of cancer patients can help us understand how cancer spreads and comes back, with the hope of creating better treatments.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT02838836

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Lowering KLF2 in immune cells to boost immunotherapy for liver cancer

  Researchers are trying to see if reducing a gene called KLF2 in certain immune cells can help immunotherapy work better for people with liver cancer.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11286851

• Improving immune therapy for liver cancer by targeting specific immune cells

  This study is looking at a new way to improve treatment for liver cancer by using a special protein in immune cells and a type of bacteria, hoping to help patients get better results from their therapy.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11172570

• Investigating how gut bacteria can enhance immune response against liver cancer

  This study is looking at how the bacteria in our gut can help treat liver cancer by using a special mouse model, and it hopes to find ways to boost the immune system and improve treatment results for people with this condition.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11076418

• Using gut bacteria to help the immune system fight liver cancer

  Researchers are seeing if changing gut bacteria can help the immune system respond better to liver cancer treatments like anti-PD-1 therapy.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-10915635

• Investigating how cholecystokinin receptors affect liver cancer

  This study is looking at how certain receptors in the body can affect liver cancer growth and spread, and it aims to find new ways to treat this type of cancer that could help patients in the future.

  NIH research Georgetown University · Washington, United States · NIH-10898070

Related topics

Quick answers

How many Hepatocellular Cancer clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (8 trials), China (2 trials), Japan (2 trials), Puerto Rico (2 trials), Taiwan (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 3, Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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