Understanding how liver conditions affect uveal melanoma spread
Exploiting oxidative stress response in uveal melanoma liver metastases
This study is looking at how uveal melanoma, a serious eye cancer that can spread to the liver, grows in that environment, with the hope of finding new treatments to help patients live longer and better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11061803 on NIH RePORTER |
What this research studies
This research focuses on uveal melanoma, a severe eye cancer that often spreads to the liver, leading to poor outcomes for patients. The team aims to explore how the liver environment influences the growth of these cancer cells and to identify new treatment strategies. By using advanced laboratory techniques, including co-culturing liver tissues with cancer cells, they will investigate the mechanisms that make these metastases resistant to current therapies. The goal is to find ways to make these cancer cells more susceptible to treatment, potentially improving patient survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with uveal melanoma who are at risk of liver metastasis.
Not a fit: Patients with uveal melanoma that has not metastasized or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for patients with metastatic uveal melanoma.
How similar studies have performed: Previous research has shown promise in targeting cancer cell vulnerabilities, suggesting that this approach could yield significant advancements in treatment.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hartsough, Edward — Drexel University
- Study coordinator: Hartsough, Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.