Understanding immune interactions in colon cancer and its spread to lymph nodes and liver
Project II: Immune regulatory circuits in primary colon cancer and lymph node and liver metastases
This study is looking at how certain immune cells behave in colon cancer and its spread to lymph nodes and the liver, to help understand why some patients don’t respond well to treatments, and it’s for people with colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10911894 on NIH RePORTER |
What this research studies
This research investigates how immune cells interact in primary colon cancer and its metastases to lymph nodes and liver. By examining the roles of specific immune cell types, such as regulatory T cells and Th17 cells, the study aims to uncover the mechanisms that allow colorectal cancer to evade treatment. The researchers will analyze tissue samples from patients with mismatch repair-proficient colorectal cancer and use advanced genetic models to simulate disease progression. This approach could lead to new insights into why some patients do not respond to existing immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with mismatch repair-proficient colorectal cancer, especially those with metastases.
Not a fit: Patients with mismatch repair-deficient colorectal cancer or those without a diagnosis of colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for colorectal cancer patients, particularly those who currently have limited options.
How similar studies have performed: Previous research has shown promise in understanding immune interactions in cancer, but this specific approach focusing on colorectal cancer and its metastases is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Rudensky, Alexander Y — Sloan-Kettering Inst Can Research
- Study coordinator: Rudensky, Alexander Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.