Understanding immune interactions in colon cancer and its spread to lymph nodes and liver
Official title: Project II: Immune regulatory circuits in primary colon cancer and lymph node and liver metastases
Funded at Sloan-Kettering Inst Can Research · NIH-10911894 · Data updated 2026-11-12
This study is looking at how certain immune cells behave in colon cancer and its spread to lymph nodes and the liver, to help understand why some patients don’t respond well to treatments, and it’s for people with colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 16, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $802,523 |
| NIH project number | 5U54CA274492-03 |
| Project ID | NIH-10911894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with mismatch repair-proficient colorectal cancer, especially those with metastases.
✕Less likely to help
Patients with mismatch repair-deficient colorectal cancer or those without a diagnosis of colorectal cancer may not benefit from this research.
What this research studies
This research investigates how immune cells interact in primary colon cancer and its metastases to lymph nodes and liver. By examining the roles of specific immune cell types, such as regulatory T cells and Th17 cells, the study aims to uncover the mechanisms that allow colorectal cancer to evade treatment. The researchers will analyze tissue samples from patients with mismatch repair-proficient colorectal cancer and use advanced genetic models to simulate disease progression. This approach could lead to new insights into why some patients do not respond to existing immunotherapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for colorectal cancer patients, particularly those who currently have limited options.
How similar studies have gone: Previous research has shown promise in understanding immune interactions in cancer, but this specific approach focusing on colorectal cancer and its metastases is relatively novel.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Rudensky, Alexander Y — Sloan-Kettering Inst Can Research
- Study coordinator: Rudensky, Alexander Y
Related research
Other NIH-funded projects on the same topics.
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Immune regulation in colon cancer and its spread to lymph nodes and liver
A patient-friendly look at how immune system circuits in colorectal cancer and its metastases may influence treatment responses and outcomes.
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Researchers are studying immune cells in liver metastases from pancreatic cancer to understand how they influence the cancer’s spread and more effective treatments.
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How DNA methylation patterns are kept in colon cancer and what happens when they’re disrupted
Researchers are studying how the molecular marks that control gene activity are maintained in colon cancer and how breaking these marks affects cancer growth and treatment response.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.