Exploring how surgery affects the immune response and liver cancer spread
Surgery triggered immune response and liver metastases
This study is looking at how exercise before surgery can help people with colorectal cancer that has spread to the liver by boosting their immune system and reducing inflammation, which might lead to better recovery and lower chances of cancer coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11075861 on NIH RePORTER |
What this research studies
This research investigates the impact of pre-operative exercise therapy on patients undergoing surgery for colorectal cancer with liver metastases. It aims to understand how exercise can modify the immune response and reduce inflammation, potentially improving surgical outcomes. By analyzing changes in immune cell behavior and function, the study seeks to identify mechanisms that could prevent cancer recurrence after surgery. Patients may be involved in exercise programs designed to enhance their recovery and overall health before surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are colorectal cancer patients scheduled for surgery, particularly those with liver metastases.
Not a fit: Patients who are not undergoing surgery or those with non-colorectal cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical outcomes and reduced recurrence of liver metastases in colorectal cancer patients.
How similar studies have performed: Previous research has shown that pre-operative exercise can positively influence surgical outcomes, suggesting that this approach may be effective in this context as well.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Tsung, Allan — University of Virginia
- Study coordinator: Tsung, Allan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.