Condition

Liquid Biopsy clinical trials and research

• 15Clinical trials
• 82NIH research projects
• 5Countries

Newest Liquid Biopsy clinical trials

All recruiting trials (15)

• Blood exosomal RNA test to rule out prostate cancer spread to bone

  This project will try a blood-based exosomal RNA test to see if it can rule out bone metastasis in people with newly diagnosed, treatment‑naïve prostate cancer scheduled for baseline PSMA PET.

  Recruiting at 9 sites Xijing Hospital · Lanzhou, Gansu and 8 other locations · NCT07553754

• ctDNA analysis on archived plasma to gauge minimal residual disease in epithelial ovarian cancer

  A single-center study will test whether ctDNA from archived and current blood samples can help identify minimal residual disease in epithelial ovarian cancer patients after surgery.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07546578

• Using urinary tumor DNA to guide how long systemic immunotherapy is given for unresectable very‑high‑risk non‑muscle‑invasive bladder cancer.

  This trial will test whether monitoring urinary tumor DNA lets people with unresectable very‑high‑risk non‑muscle‑invasive bladder cancer stop systemic immunotherapy sooner after they have a complete clinical response.

  Recruiting at 3 sites Phase 2 Tianjin Medical University Second Hospital · Tianjin and 2 other locations · NCT07475403

• Intracranial Venous Blood Sampling for Brain Tumor Liquid Biopsy

  This study tests whether taking blood from veins inside the brain can safely and reliably reveal molecular information about high-grade gliomas using a liquid biopsy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07467109

• Liquid biopsy testing to identify, monitor, and predict recurrence in urothelial carcinoma

  This project tests whether a multi-component liquid biopsy (blood and urine ctDNA, urine tumor DNA, exosomes, and protein biomarkers) can help detect disease, track treatment response, and predict recurrence in people with suspected or confirmed urothelial carcinoma.

  Recruiting Tianjin Medical University Second Hospital · Tianjin · NCT07441499

• Using urine tumor DNA to guide whether to have a second bladder tumor resection

  This study will test whether a urine tumor DNA (utDNA) test can help decide if adults with T1 or uncertain non‑muscle‑invasive bladder cancer need a second transurethral resection (re‑TURBT).

  Recruiting at 7 sites Tianjin Medical University Second Hospital · Nanchang, Anhui and 6 other locations · NCT07187635

• Using urine tumor DNA/RNA to guide second TURBT in high-risk non-muscle-invasive bladder cancer

  This test tries to see if a urine liquid biopsy measuring tumor DNA and RNA can identify which people with high-risk NMIBC need a second TURBT after initial tumor removal.

  Recruiting at 2 sites Tianjin Medical University Second Hospital · Tianjin and 1 other locations · NCT07130578

• French testing of blood-based ctDNA to find leftover cancer after surgery in Stage III colorectal cancer

  We will test whether blood-based ctDNA can find leftover cancer after surgery in people with Stage III colorectal cancer to help guide additional treatment.

  Recruiting University Hospital, Montpellier · Montpellier, Hérault · NCT06287814

• French test of leftover tumor DNA in the blood after pancreatic cancer surgery

  This will test whether a blood test for tumor DNA after surgery or after adjuvant chemotherapy can find pancreatic cancer patients at high risk of relapse.

  Recruiting University Hospital, Montpellier · Montpellier, Hérault · NCT06287749

• ctDNA blood tests to guide treatment in colorectal cancer with liver metastases

  A study using blood tests that look for tumor DNA to help decide which patients with colorectal cancer that has spread to the liver need more treatment after surgery.

  Recruiting at 2 sites University Hospital, Montpellier · Montpellier and 1 other locations · NCT06287723

• A cohort study assessing a blood test for early cancer detection in Nanjing

  This study is testing a new blood test to see if it can detect different types of cancer earlier in people aged 45-75 in Nanjing, China.

  Recruiting at 2 sites Nanjing Shihejiyin Technology, Inc. · Nanjing, Jiangsu and 1 other locations · NCT06011694

• New method for detecting melanoma biomarkers in blood samples

  This study is testing a new blood test that looks for specific markers of melanoma to see if it works better than current methods.

  Recruiting Regina Elena Cancer Institute · Rome · NCT05940311

• Observing viral biomarkers and microRNAs in oropharyngeal tumors and occult cancers related to HPV

  This study is testing if certain viral markers and microRNAs in oropharyngeal tumors can help doctors better diagnose and monitor HPV-related cancers and find new treatments.

  Recruiting Regina Elena Cancer Institute · Rome · NCT05918510

• Liver cancer immunotherapy guided by multi-omic liquid biopsy

  This project will test whether a multi-omic liquid biopsy can predict which adults with advanced (BCLC B or C) hepatocellular carcinoma will benefit from first-line PD-1/PD-L1 immunotherapy.

  Recruiting University Hospital, Montpellier · Montpellier · NCT05810402

• Collecting blood samples from lung cancer patients on targeted therapy

  This study is collecting blood samples from adults with non-small cell lung cancer who are on targeted therapy to see how their treatment is working and to check for any changes in their cancer.

  Recruiting Erasmus Medical Center · Rotterdam · NCT05221372

NIH-funded research (newest 40 of 82)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Towards a blood-based test using nanophotonic exosomes to screen and diagnose liver cancer

  A new blood test using tiny particles shed by liver cancer cells aims to screen for hepatocellular carcinoma earlier and more accurately.

  NIH research University of Houston · Houston, United States · NIH-11455308

• Liquid biopsy test to screen for lymphoma in people with HIV

  A new blood test called High Density Methyl-Seq is being checked to see if it can detect lymphoma early in people living with HIV.

  NIH research Yale University · New Haven, United States · NIH-11440158

• Liquid biopsy and oxygen therapy to guide glioblastoma treatment

  A patient-focused study exploring a blood-based test and a safe oxygen therapy to help doctors tell true tumor growth from treatment effects in adults with glioblastoma treated with chemoradiation.

  NIH research Nuvox Pharma, LLC · Tucson, United States · NIH-11420569

• Liquid biopsy to monitor LMS treatment and resistance

  A patient-centered look at using blood tests to see how well LMS treatment is working and when resistance to therapy appears.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11419797

• Imagnostix: a simple blood-based test to flag Alzheimer’s risk

  A new blood-based test called Imagnostix aims to help identify people who may be developing Alzheimer’s disease earlier and more cheaply than current methods.

  NIH research 5m Biomed, LLC · Johns Creek, United States · NIH-11417991

• Multi-omic liquid biopsy to guide immunotherapy in colorectal and anal cancers

  A patient-facing overview of a study testing blood-based biomarkers (ctDNA and extracellular RNA) to better tailor immunotherapy for colorectal and anal cancer patients.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11415692

• RBC-based test to detect early NSCLC using blood-derived tumor DNA

  A new blood test using red blood cells to find tumor DNA could help detect early non-small cell lung cancer.

  NIH research Senticell LLC · Princeton, United States · NIH-11409441

• Collaborative data hub for improving liquid biopsy cancer detection

  A nationwide collaboration will manage data and coordinate studies to improve how blood tests can detect cancer early.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11406125

• Liquid biopsy with cell-free DNA to watch sepsis in patients

  A physician-scientist is being trained over five years to use blood-based cell-free DNA as a biomarker to detect and monitor sepsis.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11387802

• Aqueous humor liquid biopsy to guide prognosis and monitoring in children with retinoblastoma

  A liquid test using a small amount of eye fluid could reveal important tumor details to help predict how retinoblastoma in young children will behave and how well treatment is working.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11384505

• Liquid biopsy for malignant effusions in metastatic breast cancer using AI-assisted tumor cell isolation

  A woman with metastatic breast cancer could benefit from a new liquid biopsy approach that uses AI to pick out tumor cells from the fluid around the organs to guide treatment.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11384165

• Liquid biopsy clues: plasma bacteria as early warning for epithelial ovarian cancer

  A patient-friendly look at a new approach that uses tiny bacteria signals in blood to help detect ovarian cancer early.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11382454

• Tuberculosis diagnosis and treatment monitoring with blood-based RNA signals

  A patient-friendly test using blood-based RNA from plasma to diagnose active TB and monitor how well treatment is working.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11382162

• Non-invasive liquid biopsy screening to predict preterm birth and complications

  A new blood-test approach aims to predict and understand preterm birth and its related conditions in pregnant people and fetuses.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11378539

• Advanced machine learning to improve blood-based cancer detection in melanoma and lung cancer

  A physician-scientist is using cutting-edge AI to make blood tests for melanoma and non-small cell lung cancer much more sensitive, so doctors can monitor cancer without relying on scans.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11370107

• ctDNA-based monitoring to guide extra treatment after colorectal cancer surgery

  A doctor-led program will use a blood test to find tiny cancer traces after surgery for Stage III colorectal cancer and see if additional therapy can improve chances of cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11362598

• Using dog and human blood tests to improve early bone cancer detection

  This project builds a blood test that uses patterns learned from dogs to help find osteosarcoma earlier in children and other patients.

  NIH research University of California at Davis · Davis, United States · NIH-11355216

• Better imaging and blood tests to guide pancreatic cancer care

  Using advanced scans and blood-based 'liquid biopsy' tests to find sooner whether treatments are working for people with pancreatic cancer.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11331308

• CRISPR-powered liquid biopsy to find endometrial cancer early

  A new, minimally invasive blood test using CRISPR technology to detect endometrial cancer and its aggressive forms, helping people at risk or with a suspected diagnosis.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11329854

• Focused ultrasound blood test to find brain tumor DNA

  This project uses focused ultrasound to gently release tumor DNA into the bloodstream so adults with brain tumors can get a less invasive molecular blood test.

  NIH research Washington University · Saint Louis, United States · NIH-11324241

• Liquid biopsy for brain tumors: using DNA methylation in blood to guide brain cancer care

  A study aims to test if measuring DNA methylation patterns in blood can reliably help diagnose brain tumors and monitor treatment without invasive brain surgery.

  NIH research University Health Network · Toronto, Canada · NIH-11319801

• Programmable blood test to detect multiple cancer DNA mutations

  A new, quick blood test designed to find multiple tumor DNA mutations to help people at risk for lung cancer get earlier, noninvasive detection.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11312147

• Blood test to track and predict neuroblastoma outcomes

  This project uses a blood test that looks for tumor DNA signals to help doctors predict outcomes and monitor children with neuroblastoma.

  NIH research University of Chicago · Chicago, United States · NIH-11309677

• Blood test to monitor multiple myeloma and guide treatment

  A blood-based test that looks for myeloma cells and cell-free DNA to track disease over time and help doctors choose better treatments for people with multiple myeloma.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11309167

• MRI and blood tests to predict prostate cancer outcomes after radiation

  This project uses repeated MRI scans and blood-based tumor markers to find early signs that predict how men with intermediate or high-risk prostate cancer do after radiation and hormone therapy.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11308340

• Liquid biopsy test to guide HER2-targeted therapy for advanced prostate cancer

  A new liquid biopsy test using blood markers to pick and guide HER2-directed therapy for men with advanced, treatment-resistant prostate cancer.

  NIH research U.s. Dept/vets Affairs Medical Center · Washington, United States · NIH-11300143

• Liquid biopsy test for lung nodules using extracellular vesicles

  A new test using tiny particles from blood to help diagnose solitary lung nodules faster and with minimal equipment, aimed at patients with lung nodules.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11292548

• Using blood tests to monitor and improve treatment for multiple myeloma

  This study is looking at a new, easier way to keep track of multiple myeloma by using blood tests instead of the more painful bone marrow biopsies, so patients can get important updates about their cancer without the stress of invasive procedures.

  NIH research University of Utah · Salt Lake City, United States · NIH-11243248

• Guidelines to improve blood and bone marrow sample handling for leukemia testing

  This project develops clear ways to collect, store, and ship blood and bone marrow so lab tests more reliably guide care for people with acute myeloid leukemia and other advanced cancers.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11196186

• Improving treatment for pancreatic cancer using advanced imaging and blood tests

  This study is looking at new ways to better manage pancreatic cancer by using advanced imaging and blood tests to quickly see how well treatments are working, so doctors can make faster decisions about care and help more patients get the right treatment when they need it.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11193860

• Blood tests to track treatment response and resistance in leiomyosarcoma

  This project checks whether a blood test that detects tumor DNA can show how well treatments work and pick up resistance in people with leiomyosarcoma.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11193263

• Blood tests plus MRI image analysis to find liver cancer earlier

  This project combines new blood-based 'liquid biopsy' tests with advanced MRI image analysis to try to detect liver cancer earlier in people at high risk, such as those with cirrhosis.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11187129

• Imagnostix — a blood test to detect Alzheimer's early

  Imagnostix is a new blood test that looks for Alzheimer's-related proteins to find early brain changes in people with memory concerns or at risk for Alzheimer's.

  NIH research 5m Biomed, LLC · Johns Creek, United States · NIH-11186422

• Blood-based EFIRM test to help clarify small lung nodules

  This project develops a blood test using EFIRM technology to detect early lung cancer in people with small indeterminate lung nodules found on CT scans.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11180269

• Multi-analyte blood and fluid tests to find breast, pancreatic cancer, and multiple myeloma earlier

  Researchers are creating combined blood and body-fluid tests to help find breast cancer, pancreatic cancer, and multiple myeloma earlier for people having screening or diagnostic workups.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11180228

• Blood exosome test to find lung cancer early and guide immunotherapy

  A blood test using tumor exosomes to find lung cancer earlier and help predict who will benefit from immunotherapy.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11179229

• Coordinating liquid biopsy efforts for early cancer detection

  This project brings together labs and hospitals to standardize and share blood-based cancer tests so they can find cancer earlier for people at risk.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11176106

• Investigating imaging and blood markers to improve prostate cancer treatment outcomes

  This study is looking to help men with intermediate and high-risk prostate cancer who are getting radiation treatment by finding early signs that show how well the treatment is working, using special imaging and blood tests, so doctors can make better decisions about their care.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11168073

• Finding early signs of preterm birth and related pregnancy complications

  This research aims to create a new blood test for expectant mothers to help identify risks for preterm birth and other pregnancy issues like preeclampsia and poor fetal growth.

  NIH research Magee-Women's Res Inst and Foundation · Pittsburgh, UNITED STATES · NIH-11167550

• AI-guided liquid biopsy to detect cancer cells in malignant fluid buildups

  This project uses AI to find and analyze cancer cells in fluids that build up in people with metastatic breast cancer to help guide treatment.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11166498

Related topics

Quick answers

How many Liquid Biopsy clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (6 trials), France (4 trials), Italy (3 trials), United States (1 trial), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →