Condition

Melanoma Stage III clinical trials and research

• 16Clinical trials
• 8Countries

Newest Melanoma Stage III clinical trials

All recruiting trials (16)

• PRTX007-003 with pembrolizumab before surgery for stage III melanoma

  This study tests whether adding the oral drug PRTX007 to pembrolizumab before surgery helps patients with resectable stage III melanoma respond better without extra safety risks.

  Recruiting at 3 sites Phase 2 Primmune Therapeutics, Inc. · Waratah, New South Wales and 6 other locations · NCT07565285

• Using Cyclophosphamide and Pembrolizumab for advanced melanoma treatment

  This study is testing if a combination of Cyclophosphamide and Pembrolizumab can help people with advanced melanoma who haven't responded to other treatments feel better and improve their health.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06771544

• Long-term follow-up for patients treated with Miltenyi CAR T therapies

  This study looks at how well Miltenyi CAR T cell therapies work and their long-term safety for patients, especially kids, who have already been treated.

  Recruiting at 2 sites Miltenyi Biomedicine GmbH · Berlin and 6 other locations · NCT06508775

• Neoadjuvant and adjuvant immunotherapy for advanced melanoma

  This study is testing if a new type of immunotherapy can help people with advanced melanoma do better before and after surgery.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT06295159

• Evaluating new treatments for advanced melanoma with pembrolizumab

  This study is testing new treatment combinations for patients with advanced melanoma who haven't responded to previous therapies to see if they can improve their chances of survival.

  Recruiting at 5 sites Phase 2 Philogen S.p.A. · Hartford, Connecticut and 6 other locations · NCT06284590

• Gene-modified TIL therapy (ADP-TILIL7) for locally advanced or metastatic melanoma

  This study will test whether a patient's own tumor-infiltrating lymphocytes, gene-modified to produce IL-7, can be safely given to adults with unresectable or metastatic melanoma who have progressed after PD-1 therapy.

  Recruiting at 2 sites Phase 1 Herlev Hospital · Herlev and 1 other locations · NCT06204991

• Analyzing PET scans and blood samples in melanoma patients receiving immunotherapy

  This study is testing if early PET scans and blood tests can help predict how well immunotherapy works for people with advanced melanoma.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06199713

• Assessing KB707 for treating advanced melanoma and solid tumors

  This study is testing a new treatment called KB707, which is a modified virus, to see if it can help adults with advanced melanoma and other solid tumors who haven't had success with regular treatments.

  Recruiting at 15 sites Phase 1/2 Krystal Biotech, Inc. · Los Angeles, California and 14 other locations · NCT05970497

• New method for detecting melanoma biomarkers in blood samples

  This study is testing a new blood test that looks for specific markers of melanoma to see if it works better than current methods.

  Recruiting Regina Elena Cancer Institute · Rome · NCT05940311

• Targeted alpha-particle therapy for advanced melanoma

  This study is testing a new treatment for advanced melanoma that uses targeted radiation to see if it can help patients whose cancer can't be surgically removed.

  Recruiting at 15 sites Phase 1/2 Perspective Therapeutics · Orange, California and 15 other locations · NCT05655312

• Stopping nivolumab early for melanoma treatment

  This study is testing if stopping nivolumab early is safe and effective for patients with advanced melanoma who have responded well to their initial treatment.

  Recruiting Erasmus Medical Center · Rotterdam · NCT05652673

• Using fecal microbiota transplantation to improve immunotherapy response in melanoma patients

  This study is testing if transferring gut bacteria from other melanoma patients can help those who haven't responded to immunotherapy feel better and improve their treatment results.

  Recruiting Phase 1/2 The Netherlands Cancer Institute · Amsterdam · NCT05251389

• Adjuvant therapy for melanoma based on treatment response

  This study tests if a combination of new medications can help people with melanoma who have a specific gene mutation stay cancer-free after their initial treatment.

  Recruiting Early Phase 1 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT04741997

• Treatment for advanced KIT-mutant melanoma using binimetinib and imatinib

  This study is testing if a combination of two medications, binimetinib and imatinib, can help people with advanced KIT-mutant melanoma feel better and manage their disease.

  Recruiting at 2 sites Phase 2 University of California, San Francisco · La Jolla, California and 1 other locations · NCT04598009

• Effect of beta-glucan on immune response in advanced melanoma patients

  This study is testing if taking beta-glucan along with Pembrolizumab can boost the immune response in patients with advanced melanoma and help them live longer without the cancer coming back.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04513028

• Investigation of encorafenib and binimetinib for advanced melanoma treatment

  This study looks at how well the combination of encorafenib and binimetinib works for people with advanced melanoma who have a specific genetic mutation and have already tried other treatments.

  Recruiting at 59 sites Pierre Fabre Pharma GmbH · Graz and 58 other locations · NCT04045691

Related topics

Quick answers

How many Melanoma Stage III clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (9 trials), Germany (3 trials), Italy (2 trials), Netherlands (2 trials), Austria (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 3, Phase 1: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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