Condition

Melanoma (Skin) clinical trials and research

• 18Clinical trials
• 6NIH research projects
• 8Countries

Newest Melanoma (Skin) clinical trials

All recruiting trials (18)

• Assessing the safety and effectiveness of ENV-501 in patients with HER3-expressing solid tumors

  This study is testing a new treatment called ENV-501 to see if it is safe and effective for people with advanced solid tumors that express HER3, like melanoma, lung cancer, and breast cancer.

  Recruiting at 5 sites Phase 1/2 Hummingbird Bioscience · La Jolla, California and 6 other locations · NCT06956690

• Assessing a test to predict treatment response in advanced melanoma patients

  This study tests if the IOpener® melanoma test can help predict how well treatment will work for people with advanced melanoma who are starting their first-line therapy.

  Recruiting at 3 sites Pamgene International B.V. · Tübingen, Baden-Wurttemberg and 2 other locations · NCT06784778

• Monitoring the effects of encorafenib and binimetinib in melanoma treatment

  This study is testing how the levels of two melanoma drugs, encorafenib and binimetinib, affect side effects and treatment success in adults with a specific type of advanced melanoma.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt · NCT06774989

• Using Cyclophosphamide and Pembrolizumab for advanced melanoma treatment

  This study is testing if a combination of Cyclophosphamide and Pembrolizumab can help people with advanced melanoma who haven't responded to other treatments feel better and improve their health.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06771544

• Skipping full lymph node removal for stage III melanoma patients who show a strong response in the index node

  This trial will see if patients with resectable stage III melanoma who get neoadjuvant ipilimumab plus nivolumab and show a major pathological response in the index lymph node can safely avoid therapeutic lymph node dissection.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT06754904

• Evaluating the DermaSensor device for detecting melanoma

  This study is testing a new device to see if it can accurately detect skin lesions that might be melanoma in people aged 40 and older.

  Recruiting at 2 sites DermaSensor, Inc. · New Smyrna Beach, Florida and 1 other locations · NCT06666790

• Personalized app for melanoma survivorship care

  This study is testing a new app designed to help people with stage I and II melanoma manage their care better and feel more empowered compared to those who receive standard care.

  Recruiting at 3 sites Erasmus Medical Center · Dordrecht, South Holland and 3 other locations · NCT06643286

• Understanding how normal skin cells change to melanoma

  This study is trying to understand how normal skin cells change into melanoma in children and young adults with certain types of moles to help improve early diagnosis and treatment.

  Recruiting at 2 sites Fundacion Clinic per a la Recerca Biomédica · Marseille and 1 other locations · NCT06605417

• Improving sun protection for rural youth to prevent skin cancer

  This study is testing a new way to help kids in rural areas of Utah and West Virginia protect themselves from the sun to prevent skin cancer.

  Recruiting University of Utah · Salt Lake City, Utah and 1 other locations · NCT06439979

• Identifying metabolic features linked to melanoma spread

  This study is trying to see if the metabolic features of melanoma tumors can help predict how the cancer spreads and affects survival in patients undergoing surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06400550

• High-intensity exercise and high-fiber diet for melanoma patients

  This study is testing whether high-intensity exercise and a high-fiber diet can help improve health for melanoma patients receiving immunotherapy.

  Recruiting Fred Hutchinson Cancer Center · Boston, Massachusetts and 1 other locations · NCT06298734

• New method for detecting melanoma biomarkers in blood samples

  This study is testing a new blood test that looks for specific markers of melanoma to see if it works better than current methods.

  Recruiting Regina Elena Cancer Institute · Rome · NCT05940311

• Combining nivolumab and relatlimab for treating melanoma that has spread to the brain

  This study is testing if combining two drugs, nivolumab and relatlimab, can help people with melanoma that has spread to the brain feel better and improve their treatment outcomes.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05704647

• Testing immune responses to predict melanoma treatment outcomes

  This study is testing if measuring certain immune signals in patients with advanced melanoma can help predict how well they will respond to a combination treatment of nivolumab and ipilimumab.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Nice · Nice, Alpes-maritimes and 2 other locations · NCT05649683

• Exploring a new cancer treatment using PeptiCRAd-1 and checkpoint inhibitors

  This study is testing a new cancer treatment that combines a special virus with immune therapy to see if it can help people with advanced cancer who haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 Valo Therapeutics Oy · Frankfurt and 6 other locations · NCT05492682

• Understanding tumor metabolism in melanoma and immunotherapy resistance

  This study is trying to see how changes in melanoma tumor cells affect their response to immunotherapy, hoping to find better treatment options for patients.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes-maritimes · NCT05307289

• Investigating genetic reasons for unusual responses to cancer treatment

  This study is trying to find out how genetic differences in cancer patients affect their responses to treatment, so doctors can tailor therapies to work better for each individual.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03740503

• Database for melanoma patients in France

  This study is creating a database of melanoma patients in France to help researchers and doctors better understand the disease and improve treatment options.

  Recruiting Nantes University Hospital · Nantes · NCT03315468

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• CivaDerm: a new four-day skin cancer radiation bandage

  A new four‑day radiation bandage for non-melanoma skin cancer aims to treat facial and other areas without multiple clinic visits or big scars.

  NIH research Civatech Oncology, INC. · Morrisville, UNITED STATES · NIH-11408990

• MOSAIC II: MAP Wound Matrix to speed graft readiness after non-melanoma skin cancer surgery

  A randomized trial tests a moldable wound scaffold (MAP Wound Matrix) to speed healing and time to graft-ready skin after head and neck cancer surgeries in adults.

  NIH research Tempo Therapeutics, INC. · San Diego, UNITED STATES · NIH-11406980

• Low-energy skin radiation patches for treating non-melanoma skin cancer

  A patient-friendly device idea uses a patch to deliver a tiny amount of radiation right at the skin to treat non-melanoma skin cancer in as few visits.

  NIH research Oncopatch, INC · Centennial, United States · NIH-11314378

• Safer medicines to prevent basal and squamous (non‑melanoma) skin cancer

  Researchers are developing new, non‑toxic oral rexinoid medicines aimed at preventing basal cell and squamous cell skin cancers, especially for people with weakened immune systems like organ transplant recipients.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11289434

• Creating safe drugs to prevent non-melanoma skin cancer

  This study is working on new medications to help prevent skin cancer in people with weakened immune systems, like those who have had organ transplants, by creating safer and more effective options that don’t have the usual side effects of current treatments.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11015805

• New ways to prevent non-melanoma skin cancer

  This study is looking for new ways to help prevent non-melanoma skin cancers, like basal cell and squamous cell carcinoma, by understanding how these cancers develop and testing new treatments that could lower your risk.

  NIH research University of Arizona · Tucson, United States · NIH-10686365

Related topics

Quick answers

How many Melanoma (Skin) clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (7 trials), France (5 trials), Germany (2 trials), Italy (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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