Condition

Lymph Node Metastasis clinical trials and research

• 14Clinical trials
• 5NIH research projects
• 9Countries

Newest Lymph Node Metastasis clinical trials

All recruiting trials (14)

• Irreversible electroporation to treat recurrent or metastatic neck lymph nodes from thyroid cancer

  This will try ultrasound-guided irreversible electroporation (IRE) to destroy recurrent or metastatic cervical lymph nodes in adults with thyroid cancer who have already had thyroid surgery and neck dissection.

  Recruiting at 3 sites First Affiliated Hospital of Zhejiang University · Guangzhou, Guangdong and 2 other locations · NCT07328243

• Finding tiny amounts of tumor DNA in the blood after surgery for early HR+/HER2- breast cancer with 1–3 positive lymph nodes

  This project tests whether a blood test that finds tiny bits of tumor DNA after surgery can identify people with early HR+/HER2- breast cancer and 1–3 positive lymph nodes who are more likely to have the cancer come back, including a dedicated group of African American women.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07025785

• AI model for diagnosing lymph node metastasis in nasopharyngeal carcinoma

  This study is testing a new AI tool that helps doctors diagnose if nasopharyngeal carcinoma has spread to lymph nodes by looking at MRI images before and after chemotherapy.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT06829147

• Comparing neck observation and elective neck dissection for early-stage oral cancer

  This study is testing whether watching the neck or doing surgery to remove lymph nodes is better for people with early-stage oral cancer in terms of survival and quality of life.

  Recruiting Huashan Hospital · Shanghai · NCT06623266

• Using robotic ultrasound to evaluate lymph nodes in gynecological cancers

  This study is testing a new robotic ultrasound method to see if it can help women with gynecological cancers check their lymph nodes during surgery, aiming to reduce the need for more invasive procedures.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06621823

• Enhanced MRI for detecting lymph node metastasis in head and neck cancer

  This study is testing a new MRI contrast agent to see if it can help doctors better detect cancer spread in lymph nodes for people with head and neck cancer.

  Recruiting Phase 1 MegaPro Biomedical Co. Ltd. · Taipei · NCT06540443

• Evaluating new methods for classifying lymph nodes in cancer patients

  This study is testing a new way to classify lymph nodes in cancer patients to see if it helps doctors make better treatment decisions.

  Recruiting Copernicus Memorial Hospital · Krakow and 5 other locations · NCT06527027

• Ultrasound surveillance for vulvar cancer treatment

  This study is testing if regular ultrasound check-ups can be a safer alternative to surgery for women with vulvar cancer to monitor lymph node involvement.

  Recruiting at 3 sites Queensland Centre for Gynaecological Cancer · Brisbane, Queensland and 4 other locations · NCT06264167

• Maximizing lymph node removal from lung surgery specimens

  This project will try a standardized dissection method to remove more lymph nodes from lung cancer surgery specimens so staging is more accurate for people having lobectomy without prior treatment.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06252129

• Investigating lymph node metastasis in pancreatic cancer surgery

  This study is testing whether removing certain lymph nodes during pancreatic cancer surgery can help doctors understand how the cancer spreads and improve treatment for patients.

  Recruiting at 2 sites Uppsala University Hospital · Odense and 5 other locations · NCT06065891

• Selective lymph node dissection for early-stage lung cancer

  This study is testing if a specific type of surgery called selective lymph node dissection can help people with early-stage lung cancer live longer and stay cancer-free.

  Recruiting Phase 3 Fudan University · Shanghai, Please Select · NCT06031246

• Observing viral biomarkers and microRNAs in oropharyngeal tumors and occult cancers related to HPV

  This study is testing if certain viral markers and microRNAs in oropharyngeal tumors can help doctors better diagnose and monitor HPV-related cancers and find new treatments.

  Recruiting Regina Elena Cancer Institute · Rome · NCT05918510

• Investigating the Role of Lymph Nodes in Lung Cancer with Pleural Invasion

  This study is trying to see if checking certain lymph nodes can help doctors better understand and treat patients with non-small cell lung cancer that has spread to the pleura.

  Recruiting Luzerner Kantonsspital · Lucerne · NCT05596578

• Using advanced navigation systems for lymph node surgery in urologic cancer

  This study is testing if using advanced navigation systems during lymph node surgery can help improve outcomes for patients with urologic cancer.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05132283

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Lymph node metastasis and immune tolerance in head and neck cancer

  A study in people with head and neck cancer looks at how cancer spread to lymph nodes may shape the immune system and help tumors grow.

  NIH research Stanford University · Stanford, United States · NIH-11614785

• A smarter radiomics tool to predict lymph node cancer spread for targeted neck cancer radiation

  A new radiomics model uses imaging data to predict which cervical lymph nodes are cancerous so doctors can tailor radiation therapy for head and neck cancer.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11372242

• Better Radiation Planning for Head and Neck Cancer

  This work aims to use advanced imaging to accurately find cancer in lymph nodes for people with head and neck cancer, helping doctors target radiation more precisely.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11128695

• How lymph node metastasis affects the body's immune response to tumors

  This study is looking at how cancer spreading to lymph nodes affects the body's immune response, especially in people with melanoma and other solid tumors, to find new ways to boost the immune system's ability to fight cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-10996877

• A model to predict lymph node cancer spread for targeted radiation therapy

  This study is looking to develop a smart tool that uses special imaging to figure out if lymph nodes in the neck have cancer, so that only the ones that really need treatment get targeted radiation, helping to avoid unnecessary side effects for patients.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10873881

Related topics

Quick answers

How many Lymph Node Metastasis clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in China (4 trials), United States (3 trials), Italy (2 trials), Poland (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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