Aqueous humor liquid biopsy to guide prognosis and monitoring in children with retinoblastoma

Who could benefit from this research

What this research studies

This project uses fluid from the eye to capture tumor DNA and identify genetic changes in retinoblastoma, offering a noninvasive way to learn about a child’s cancer. Researchers have already shown that this eye fluid can reflect tumor DNA and specific biomarkers, and they will refine and validate a test that detects crucial genetic alterations. The goal is to relate what the liquid biopsy finds to how aggressive the cancer is and how it may respond to therapy, without needing tumor tissue. The study is led by a pediatric oncology and ophthalmology team at Children’s Hospital of Los Angeles, focusing on children from infancy to early school-age years. Outcomes could pave the way for personalized monitoring and treatment decisions based on a simple eye fluid sample.

Why it matters

Where this research is happening

• Children's Hospital of Los Angeles
  Los Angeles, United States Active

Researchers

• Principal investigator: Berry, Jesse L — Children's Hospital of Los Angeles
• Study coordinator: Berry, Jesse L

Related research

Other NIH-funded projects on the same topics.

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• Liquid biopsy to monitor LMS treatment and resistance

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  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11419797

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.