Condition

Melanoma Stage IV clinical trials and research

• 22Clinical trials
• 11Countries

Newest Melanoma Stage IV clinical trials

All recruiting trials (22)

• NeoAdjuvant PD-1–Based Therapy in Resectable Advanced Melanoma (NASA)

  In people with resectable stage IIIB–IV melanoma, this study tests whether two infusions of pembrolizumab or a combination of ipilimumab plus nivolumab given before surgery can keep people alive at 2 years without needing additional adjuvant therapy.

  Recruiting Phase 2 UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07740941

• Urinary microbiome as a biomarker for melanoma diagnosis and treatment response

  This study tests whether bacteria in urine can help diagnose melanoma and predict how well patients will respond to systemic therapy.

  Recruiting Medical University of Graz · Gratwein, Styria · NCT07635732

• Using Cyclophosphamide and Pembrolizumab for advanced melanoma treatment

  This study is testing if a combination of Cyclophosphamide and Pembrolizumab can help people with advanced melanoma who haven't responded to other treatments feel better and improve their health.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06771544

• Long-term follow-up for patients treated with Miltenyi CAR T therapies

  This study looks at how well Miltenyi CAR T cell therapies work and their long-term safety for patients, especially kids, who have already been treated.

  Recruiting at 2 sites Miltenyi Biomedicine GmbH · Berlin and 6 other locations · NCT06508775

• Treatment of advanced solid tumors with VET3-TGI immunotherapy

  This study is testing a new cancer treatment called VET3-TGI to see if it can safely target and kill cancer cells in patients with advanced solid tumors, either by injecting it directly into the tumors or giving it through an IV.

  Recruiting at 7 sites Phase 1 KaliVir Immunotherapeutics · Los Angeles, California and 6 other locations · NCT06444815

• Testing GIM-531 for advanced solid tumors

  This study is testing a new oral medication called GIM-531 to see if it can help people with advanced solid tumors, especially those with melanoma that hasn't improved after other treatments.

  Recruiting at 11 sites Phase 1/2 Georgiamune Inc · Scottsdale, Arizona and 10 other locations · NCT06425926

• Detecting and clearing residual disease in high-risk melanoma patients

  This study is testing if a new combination treatment for high-risk melanoma can help patients with leftover cancer cells in their blood feel better compared to the usual treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06319196

• Neoadjuvant and adjuvant immunotherapy for advanced melanoma

  This study is testing if a new type of immunotherapy can help people with advanced melanoma do better before and after surgery.

  Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT06295159

• Evaluating new treatments for advanced melanoma with pembrolizumab

  This study is testing new treatment combinations for patients with advanced melanoma who haven't responded to previous therapies to see if they can improve their chances of survival.

  Recruiting at 5 sites Phase 2 Philogen S.p.A. · Hartford, Connecticut and 6 other locations · NCT06284590

• Gene-modified TIL therapy (ADP-TILIL7) for locally advanced or metastatic melanoma

  This study will test whether a patient's own tumor-infiltrating lymphocytes, gene-modified to produce IL-7, can be safely given to adults with unresectable or metastatic melanoma who have progressed after PD-1 therapy.

  Recruiting at 2 sites Phase 1 Herlev Hospital · Herlev and 1 other locations · NCT06204991

• Analyzing PET scans and blood samples in melanoma patients receiving immunotherapy

  This study is testing if early PET scans and blood tests can help predict how well immunotherapy works for people with advanced melanoma.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT06199713

• Assessing KB707 for treating advanced melanoma and solid tumors

  This study is testing a new treatment called KB707, which is a modified virus, to see if it can help adults with advanced melanoma and other solid tumors who haven't had success with regular treatments.

  Recruiting at 15 sites Phase 1/2 Krystal Biotech, Inc. · Los Angeles, California and 14 other locations · NCT05970497

• New method for detecting melanoma biomarkers in blood samples

  This study is testing a new blood test that looks for specific markers of melanoma to see if it works better than current methods.

  Recruiting Regina Elena Cancer Institute · Rome · NCT05940311

• Targeted alpha-particle therapy for advanced melanoma

  This study is testing a new treatment for advanced melanoma that uses targeted radiation to see if it can help patients whose cancer can't be surgically removed.

  Recruiting at 15 sites Phase 1/2 Perspective Therapeutics · Orange, California and 15 other locations · NCT05655312

• Stopping nivolumab early for melanoma treatment

  This study is testing if stopping nivolumab early is safe and effective for patients with advanced melanoma who have responded well to their initial treatment.

  Recruiting Erasmus Medical Center · Rotterdam · NCT05652673

• Infusion of engineered lymphocytes for patients with NY-ESO-1 expressing metastatic cancers

  This study is testing a new treatment using specially modified immune cells to see if it can help people with certain advanced cancers that have the NY-ESO-1 marker.

  Recruiting Phase 1/2 Hadassah Medical Organization · Jerusalem · NCT05296564

• Using fecal microbiota transplantation to improve immunotherapy response in melanoma patients

  This study is testing if transferring gut bacteria from other melanoma patients can help those who haven't responded to immunotherapy feel better and improve their treatment results.

  Recruiting Phase 1/2 The Netherlands Cancer Institute · Amsterdam · NCT05251389

• Adjuvant therapy for melanoma based on treatment response

  This study tests if a combination of new medications can help people with melanoma who have a specific gene mutation stay cancer-free after their initial treatment.

  Recruiting Early Phase 1 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT04741997

• Treatment for advanced KIT-mutant melanoma using binimetinib and imatinib

  This study is testing if a combination of two medications, binimetinib and imatinib, can help people with advanced KIT-mutant melanoma feel better and manage their disease.

  Recruiting at 2 sites Phase 2 University of California, San Francisco · La Jolla, California and 1 other locations · NCT04598009

• Effect of beta-glucan on immune response in advanced melanoma patients

  This study is testing if taking beta-glucan along with Pembrolizumab can boost the immune response in patients with advanced melanoma and help them live longer without the cancer coming back.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04513028

• Investigation of encorafenib and binimetinib for advanced melanoma treatment

  This study looks at how well the combination of encorafenib and binimetinib works for people with advanced melanoma who have a specific genetic mutation and have already tried other treatments.

  Recruiting at 59 sites Pierre Fabre Pharma GmbH · Graz and 58 other locations · NCT04045691

• Combining immunotherapy and radiotherapy for melanoma brain metastases

  This study is testing if combining two immune therapies with targeted radiation can help people with melanoma that has spread to the brain feel better and live longer.

  Recruiting at 8 sites Phase 2 Melanoma Institute Australia · Sydney, New South Wales and 8 other locations · NCT03340129

Related topics

Quick answers

How many Melanoma Stage IV clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (12 trials), Germany (3 trials), Italy (2 trials), Austria (2 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 5, Phase 1: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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