Liquid biopsy test for lung nodules using extracellular vesicles
Official title: Liquid biopsy of solitary pulmonary nodule with extracellular vesicles
Funded at State University of Ny,binghamton · NIH-11292548 · Data updated 2026-11-12
A new test using tiny particles from blood to help diagnose solitary lung nodules faster and with minimal equipment, aimed at patients with lung nodules.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $579,559 |
| NIH project number | 4R37CA255948-06 |
| Project ID | NIH-11292548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with solitary pulmonary nodules who may need diagnostic clarification.
✕Less likely to help
Patients with nodules that are clearly benign or clearly malignant may not need new diagnostic approaches.
What this research studies
This project aims to create a blood-based test that uses extracellular vesicles and a targeted gene panel to distinguish malignant from benign lung nodules. It includes a microdevice to capture EVs and a streamlined 21-gene panel, with plans to compare EV DNA mutations to tissue mutations and to study differences by smoking status and sex. The work also features an AI tool to identify nodules and classify them, plus researchers are exploring faster nucleic acid assays that could work without specialized machines. Patients could benefit from quicker, less invasive diagnostics and improved precision in PN decision-making.
Why it matters
Potential benefit: If successful, patients may get faster and more accurate diagnoses from a simple blood test, reducing unnecessary procedures.
How similar studies have gone: Previous work in liquid biopsy and EV-based diagnostics has shown promise in related lung cancer research, with ongoing optimization.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Wan, Yuan — State University of Ny,binghamton
- Study coordinator: Wan, Yuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.