Condition

Immune Checkpoint Inhibitor clinical trials and research

• 16Clinical trials
• 36NIH research projects
• 4Countries

Newest Immune Checkpoint Inhibitor clinical trials

All recruiting trials (16)

• Granzyme B-PET to see if immunotherapy works in TNBC

  This study will test whether a Granzyme B PET/CT scan can help predict how well immunotherapy will work for adults with locally advanced or metastatic triple-negative breast cancer receiving an immune checkpoint inhibitor.

  Recruiting Fudan University · Shanghai · NCT07705438

• Thymosin Alpha-1 plus PD-1 therapy in older adults with advanced melanoma

  This trial tests whether adding Thymosin Alpha-1 to a PD-1 antibody helps people age 60 and up with advanced melanoma.

  Recruiting at 2 sites Phase 2 Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT07644897

• Intestinal Low-Dose Radiotherapy plus Immunochemotherapy to Convert Borderline Resectable or Unresectable Esophageal Squamous Cell Carcinoma

  This study tests whether adding a very low dose intestinal radiotherapy with immunochemotherapy can make advanced esophageal squamous cell carcinoma operable for patients who can’t be surgically removed today.

  Recruiting Phase 2 Shantou University Medical College · Shantou, Guangdong · NCT07339488

• PRaG-1 Plus PRaG Therapy with Radiation and Immunotherapy in Older Adults with Advanced Solid Tumors

  This study tests whether giving PRaG-1 Cordycepin tablets together with radiation, immune-boosting injections, and PD-1/PD-L1 inhibitors can help people aged 65 and older with advanced solid tumors.

  Recruiting Phase 2 Second Affiliated Hospital of Soochow University · Suzhou, Jiangsu · NCT07267234

• Post-surgery radiotherapy plus sintilimab versus TACE for liver cancer with narrow surgical margins

  This trial will try to see if adding radiotherapy and the immunotherapy drug sintilimab after curative liver cancer surgery prevents recurrence better than TACE in patients with narrow surgical margins and other high-risk features.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT07186621

• Lattice radiation combined with immunotherapy for advanced solid tumors

  This trial will test whether combining lattice (spatially fractionated) radiation with immunotherapy helps people with advanced or metastatic solid tumors.

  Recruiting at 3 sites Phase 2 Tianjin Medical University Cancer Institute and Hospital · Beijing, Beijing Municipality and 2 other locations · NCT07058948

• Examining LAG3 Expression in Triple Negative Breast Cancer

  This study is testing how a protein called LAG-3 affects treatment outcomes in patients with triple negative breast cancer who are receiving chemotherapy along with an immune therapy.

  Recruiting Samsung Medical Center · Seoul · NCT06259162

• Multimodal radiotherapy for advanced renal cell carcinoma after immunotherapy

  This study is testing whether combining different types of radiation therapy with ongoing treatment can help people with advanced kidney cancer who haven't responded well to previous immunotherapy.

  Recruiting Phase 2 Jinling Hospital, China · Nanjing, Jiangsu · NCT06255223

• Analyzing blood and tumor markers to predict response to immunotherapy in advanced cancer

  This study is testing if blood and tumor markers can help predict how well people with advanced cancer will respond to immunotherapy treatments.

  Recruiting Gene Solutions · Ho Chi Minh City, Hồ Chí Minh and 1 other locations · NCT06227728

• Assessing safety of combining radiotherapy with new systemic therapies for breast cancer

  This study is testing if it's safe to give new breast cancer treatments together with radiation therapy to see if they can work well together for patients who need both.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06197581

• Evaluating COVID-19 vaccine effectiveness in lung cancer patients

  This study is testing whether getting a COVID-19 booster shot helps lung cancer patients on treatment avoid severe infections and stay healthier compared to those who don’t get the booster.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT06168032

• Induction chemotherapy with low-dose radiation and cadonilimab for locally advanced nasopharyngeal carcinoma

  This study will try adding low-dose radiation and the immune drug cadonilimab to induction chemotherapy before standard concurrent chemoradiotherapy in adults with newly diagnosed locally advanced nasopharyngeal carcinoma.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong and 2 other locations · NCT05941741

• Liver cancer immunotherapy guided by multi-omic liquid biopsy

  This project will test whether a multi-omic liquid biopsy can predict which adults with advanced (BCLC B or C) hepatocellular carcinoma will benefit from first-line PD-1/PD-L1 immunotherapy.

  Recruiting University Hospital, Montpellier · Montpellier · NCT05810402

• Assessment of cardiovascular issues in cancer patients on immune checkpoint inhibitors

  This study is trying to see if cancer patients treated with immune checkpoint inhibitors have heart problems and how those issues affect their health.

  Recruiting Institut Mutualiste Montsouris · Paris · NCT05799898

• Combining advanced radiotherapy with immune therapy for lung cancer

  This study is testing a new treatment for advanced lung cancer that combines special radiation therapy with immune therapy to see if it can help patients feel better and improve their outcomes.

  Recruiting Xinqiao Hospital of Chongqing · Chongqing, Chongqing Municipality and 1 other locations · NCT05754203

• Combining toripalimab with chemotherapy for advanced gastric cancer

  This study is testing if combining a new drug called toripalimab with chemotherapy can help people with advanced stomach cancer do better before surgery.

  Recruiting Phase 2 Henan Cancer Hospital · Zhengzhou, Henan · NCT04891016

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Autoimmune diabetes linked to cancer immunotherapy: discovering causes and biomarkers

  This grant explores why some people on cancer immunotherapy develop autoimmune diabetes and aims to find biomarkers to predict and prevent it.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11415176

• ctDNA biomarker to guide safety of cancer immunotherapy in inflammatory arthritis

  A patient-facing biomarker study using a blood test to detect tumor DNA in people with cancer who develop inflammatory arthritis from immunotherapy, to help doctors pick safer treatment choices.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11411495

• Cross-species study of immune responses to cancer immunotherapy in dogs and humans with invasive bladder cancer

  A study using dogs with naturally occurring invasive bladder cancer to help improve immune checkpoint therapies for people with the same disease.

  NIH research Purdue University · West Lafayette, United States · NIH-11411241

• Characterizing the psychological symptoms in melanoma patients on immunotherapy

  A long-term study follows adults with advanced skin cancer who are starting immune checkpoint therapy to understand the pattern of emotional and psychological symptoms they experience.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11402003

• Immunologic and Antigenic Drivers of Immune Checkpoint Inhibitor–Associated Heart Inflammation

  A doctor-scientist team is studying why cancer patients treated with immune checkpoint drugs sometimes develop dangerous heart inflammation and what immune targets cause it.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11388127

• Pathway-guided treatment of colon toxicity from immune checkpoint inhibitors

  A patient-focused look at a study that aims to understand and improve how immune checkpoint inhibitor therapy causes colon inflammation and how to treat it more effectively.

  NIH research Northwestern University · Chicago, United States · NIH-11384653

• Understanding how T cells and heart cells talk in a life-threatening heart inflammation from cancer immunotherapy

  A doctor–scientist will study how immune T cells interact with heart cells in people treated for cancer who develop dangerous inflammation from immune checkpoint inhibitors.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11377701

• Rapid diagnosis and treatment response in immune therapy-related kidney injury

  A study to find real-time biomarkers to diagnose ICI-related kidney injury and predict whether steroids will work, so patients on cancer immunotherapy get faster, better treatment.

  NIH research Yale University · New Haven, United States · NIH-11369158

• Steroid-sparing treatments for kidney inflammation caused by cancer immunotherapy

  This compares steroid-sparing immune medicines with standard steroid treatment for people who develop kidney inflammation after cancer immunotherapy.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11366576

• Understanding immune-triggered inflammatory arthritis from cancer immunotherapy

  A clinical study looks at why inflammatory arthritis caused by cancer immunotherapy affects people differently and how to best treat it.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11365141

• Disparities in Immunotherapy Outcomes for African Ancestry Cancer Patients in Community Settings

  This project follows cancer patients treated with anti-PD-1/PD-L1 therapies in community clinics to understand how racial background may influence treatment results and side effects.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11362040

• How cancer immunotherapy can cause sudden or lasting kidney damage

  This project aims to learn why some people who get immune checkpoint inhibitor cancer drugs develop sudden or long-term kidney problems.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11332839

• Easing psychological symptoms in women with breast cancer through moderate aerobic exercise

  This project finds out if a regular program of moderate aerobic exercise can reduce anxiety and related psychological symptoms in women undergoing breast cancer treatment while exploring personal, neighborhood, and blood-based (epigenetic) factors that might explain who benefits most.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11328765

• Gut-targeted IL-10 therapy to prevent gut inflammation from cancer immunotherapy

  A tiny, engineered yeast delivers a calming immune protein directly in the gut to prevent colitis in people treated with immune checkpoint inhibitors.

  NIH research Fzata, INC. · Halethorpe, United States · NIH-11314083

• Gut bacteria that help immunotherapy fight melanoma

  This project explores whether certain gut bacteria and their natural chemicals can help immunotherapy work better for people with melanoma.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11310869

• Exosome markers to tell if kidney cancer immunotherapy is working

  We will look for proteins and RNA in blood and urine exosomes to see if they can show early whether immunotherapy helps people with metastatic kidney cancer.

  NIH research Stanford University · Stanford, United States · NIH-11308288

• Using AI to find tissue and genetic markers to guide immune therapy for stomach cancer

  This project uses artificial intelligence to find tissue and genomic signs that help doctors choose and improve immune checkpoint drugs for people with gastric (stomach) cancer.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11294323

• Targeted Internal Radiation and Immune Therapy for Non-Muscle-Invasive Bladder Cancer

  Aims to help people with early bladder cancer that doesn’t respond to current therapy by using a novel intravesical treatment that combines targeted radiation, immune checkpoint inhibitors, and oncolytic virus to trigger a strong anti-cancer response.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11280102

• Platelet-aided immunotherapy for triple-negative breast cancer

  Researchers are using platelets to carry PD-L1 blocking drugs directly to triple-negative breast tumors to help the immune system attack them.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11252603

• Understanding and Treating Kidney Problems from Cancer Immunotherapy

  This project looks for better ways to quickly identify and treat kidney inflammation that can happen to people receiving certain cancer treatments.

  NIH research Yale University · New Haven, United States · NIH-11164743

• Improving immunotherapy for invasive bladder cancer using insights from dogs and people

  This project compares immune responses and immunotherapy effects in people and pet dogs with invasive bladder cancer to find clues that could help more patients benefit from checkpoint drugs.

  NIH research Purdue University · West Lafayette, United States · NIH-11163412

• Targeted treatment for colon inflammation caused by cancer immunotherapy

  This project will try treatments that target specific immune pathways to help people who develop colon inflammation (colitis) from immune checkpoint inhibitor cancer therapies.

  NIH research Northwestern University · Chicago, United States · NIH-11143155

• How certain bacteria can enhance cancer treatment effectiveness

  This study is looking at how certain good bacteria in your gut might help make cancer treatments work better for melanoma patients by boosting the immune system, especially the cells that fight tumors, and it hopes to find new ways to improve treatment for those who haven't had success with current options.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11131468

• Identifying early responses to kidney cancer treatment using exosomes

  This study is looking at tiny particles called exosomes in blood and urine to see if they can help doctors tell how well patients with advanced kidney cancer are responding to a combination treatment, so patients can get the right care faster and avoid treatments that aren't working.

  NIH research Stanford University · Stanford, United States · NIH-11114815

• Understanding kidney problems caused by cancer immunotherapy

  This study is looking at how certain cancer treatments can sometimes harm the kidneys, and it's for patients who have had kidney problems after these treatments; by examining samples from these patients, researchers hope to understand why this happens and find ways to prevent or fix these issues.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11092222

• Understanding heart inflammation caused by cancer immunotherapy

  This study is looking at how certain cancer treatments can sometimes cause heart inflammation called myocarditis, and it's for patients who are receiving these immunotherapy drugs; the researchers want to understand how this happens so they can help improve care for those affected.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11082466

• Understanding Immune Checkpoint Inhibitor Treatment Outcomes in Cancer Survivors

  This project looks at how immune checkpoint inhibitor treatments work for cancer survivors, especially those of African ancestry, in everyday cancer clinics.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11074667

• Using AI to find biomarkers that improve treatment for gastric cancer

  This study is looking to help people with gastric cancer by using artificial intelligence to find clues that show who might respond well to certain immune treatments, so they can get the best care possible.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11063978

• Improving delivery of immune therapy for triple-negative breast cancer

  This study is looking at a new way to help patients with triple-negative breast cancer by using platelets to deliver immune treatments directly to the tumor, which could make the treatment work better and help the body fight the cancer more effectively.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11049687

• Understanding skin-related side effects of cancer immunotherapy

  This study is looking at skin problems that some cancer patients might experience while getting immune checkpoint inhibitors, with the goal of understanding how common these issues are and what might cause them, so we can help patients feel better and keep up with their important treatments.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11045671

• Understanding how T-cells cause heart inflammation from cancer treatments

  This study is looking into how certain cancer treatments can sometimes cause heart inflammation, and it aims to understand how specific immune cells might be causing this issue, so we can find better ways to protect the heart for patients undergoing these therapies.

  NIH research Stanford University · Stanford, United States · NIH-11007197

• Understanding kidney issues caused by cancer immunotherapy

  This study is looking for a special marker in the blood that can help doctors understand and treat kidney problems caused by cancer medications, so they can better help patients who might not respond to regular treatments.

  NIH research Yale University · New Haven, United States · NIH-10940754

• Exploring immune responses in dogs and humans with bladder cancer

  This study is looking at how a type of cancer treatment called immune checkpoint inhibitors works for both dogs and humans with bladder cancer, hoping to find ways to make the treatment better for everyone.

  NIH research Purdue University · West Lafayette, United States · NIH-10926920

• Understanding and treating colon toxicity from cancer immunotherapy

  This study is looking into the side effects of certain cancer treatments that can cause serious inflammation in the colon, called ICI-colitis, to find better ways to help patients feel better while still getting their cancer care.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10894831

• Understanding side effects in melanoma patients treated with immune therapy

  This study is looking at the side effects that melanoma patients might experience while getting treatment with immune checkpoint inhibitors, to better understand how these treatments can help them live longer but may also cause some uncomfortable issues, and it’s for anyone who wants to know more about the long-term ef

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10893992

• Understanding immune changes in arthritis caused by cancer treatments

  This study is looking at how a cancer treatment called immune checkpoint inhibitors might cause joint pain and inflammation in some patients, and it aims to understand how the immune system, especially certain immune cells, is involved in this process to help improve care for those affected.

  NIH research Yale University · New Haven, United States · NIH-10892882

Related topics

Quick answers

How many Immune Checkpoint Inhibitor clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (12 trials), France (2 trials), South Korea (1 trial), Vietnam (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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