Implementing multi-component approaches to help blood donors with familial hypercholesterolemia(

Who could benefit from this research

What this research studies

This project plans to identify barriers to treatment for donors with familial hypercholesterolemia and to create a practical set of strategies that can be used at community blood donation sites. It will use interviews and theory-driven methods to develop and test an implementation bundle aimed at increasing access to LDL-C-lowering therapy. The study will pilot the bundle in a real blood-donor setting and use mixed methods to understand what helps or hinders uptake of treatment. The work is led by UT Southwestern and addresses how the donation system can connect individuals with needed care.

Why it matters

Where this research is happening

• Ut Southwestern Medical Center
  Dallas, United States Active

Researchers

• Principal investigator: Khera, Amit — Ut Southwestern Medical Center
• Study coordinator: Khera, Amit

Related research

Other NIH-funded projects on the same topics.

• Using behavioral nudges to improve family screening for inherited high cholesterol

  This project uses two patient-facing approaches based on behavioral economics to help people with familial hypercholesterolemia get their relatives screened for the condition.

  NIH research Northwestern University · Chicago, United States · NIH-11392680

• Improving Risk Stratification for Familial Hypercholesterolemia (FH)

  A patient-facing look at a study that aims to better predict who with familial hypercholesterolemia is at highest risk for early heart disease.

  NIH research Geisinger Clinic · Danville, United States · NIH-11379914

• Nonviral CRISPR-Cas9 delivery to liver cells to treat familial hypercholesterolemia

  A new approach uses nonviral methods to deliver CRISPR-Cas9 to liver cells and select edited cells with acetaminophen, aiming to permanently lower bad cholesterol in people with familial hypercholesterolemia.

  NIH research Clemson University · Clemson, United States · NIH-11370567

• Helping families find and treat inherited high cholesterol

  This project tests a clinic-based program to help primary care doctors find and treat children and adults with inherited high cholesterol (familial hypercholesterolemia).

  NIH research Geisinger Clinic · Danville, United States · NIH-11304545

• Familial hypercholesterolemia: closing gaps in prevention of heart disease

  A new NIH grant is exploring why people with familial hypercholesterolemia often go undiagnosed or receive uneven care, with the goal of improving early detection and prevention of heart disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11293026

• Better heart-risk prediction for inherited high cholesterol

  This project aims to give people with familial high cholesterol clearer, more personalized estimates of their future heart disease risk using genetic information, cholesterol measures, and other health factors.

  NIH research Geisinger Clinic · Danville, United States · NIH-11158873

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.