Condition

Hypertriglyceridemia clinical trials and research

• 11Clinical trials
• 2NIH research projects
• 12Countries

Newest Hypertriglyceridemia clinical trials

All recruiting trials (11)

• Ion775 for high triglyceride levels: safety, tolerability, and how well it works

  A drug called ION775 is being tested to see if it can safely lower fasting triglycerides in adults with hypertriglyceridemia or severe hypertriglyceridemia who are already on standard lipid medicines.

  Recruiting at 17 sites Phase 2 Ionis Pharmaceuticals, Inc. · Lincoln, California and 17 other locations · NCT07604974

• Russian registry for people with very high triglycerides

  This registry collects health and genetic information from people in Russia who have very high triglycerides (≥10 mmol/L) to see what their causes, care, and outcomes look like.

  Recruiting at 6 sites Russian Cardiology Research and Production Center · Astrakhan and 5 other locations · NCT07508930

• CTX310 for refractory high triglycerides or LDL cholesterol

  This trial will test whether a single IV dose of CTX310 is safe and tolerated in adults whose high triglycerides or LDL cholesterol have not responded to available treatments.

  Recruiting at 16 sites Phase 1 CRISPR Therapeutics · Hialeah, Florida and 16 other locations · NCT07491172

• High-speed centrifugation to enable anti-Xa testing on lipemic (fatty) blood samples

  This will test whether spinning fatty (lipemic) blood samples very fast helps the lab get accurate anti-Xa measurements for adults on anti-Xa anticoagulant medications.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07200674

• MAR001 for adults with high triglycerides and remnant cholesterol

  This trial will try the drug MAR001 to lower post-meal triglycerides and remnant cholesterol in adults with elevated triglyceride levels.

  Recruiting Phase 2 Marea Therapeutics · Chula Vista, California · NCT07199309

• JMT202 injections for adults with high triglycerides

  This will test whether repeated subcutaneous injections of JMT202 are safe and well tolerated in Chinese adults with high triglyceride levels.

  Recruiting Phase 1/2 Shanghai JMT-Bio Inc. · Beijing, Beijing Municipality · NCT07140809

• MAR001 in adults with high triglycerides and remnant cholesterol

  This study tests MAR001 against placebo to see if it lowers triglycerides and remnant cholesterol in adults with elevated levels.

  Recruiting at 21 sites Phase 2 Marea Therapeutics · Anniston, Alabama and 54 other locations · NCT07028749

• Adding chia and pumpkin seeds to a recommended diet to lower triglycerides and change blood fat composition

  This study tries to see if adding chia and pumpkin seeds to a heart-healthy (NCEP-ATPIII) diet lowers triglycerides in adults with high triglyceride levels.

  Recruiting Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran · Mexico City, Mexico City · NCT07004777

• EPA versus DHA fish oil: effects on blood clotting and cholesterol

  This study will test whether taking four grams a day of either EPA or DHA fish oil for eight weeks changes blood lipids and clotting markers in adults with high triglycerides and low HDL.

  Recruiting Early Phase 1 The Miriam Hospital · Providence, Rhode Island · NCT06494488

• Testing a new gene editing treatment for patients with high cholesterol

  This study is testing a new gene editing treatment to see if it can safely lower cholesterol levels in people with high cholesterol that doesn't respond to other treatments.

  Recruiting at 18 sites Phase 1 Verve Therapeutics, Inc. · Garden Grove, California and 17 other locations · NCT06451770

• Effect of Vitamin C on Triglyceride Levels in Critical Care Patients

  This study is testing if giving vitamin C through an IV can help lower triglyceride levels in critically ill patients in the ICU.

  Recruiting Meir Medical Center · Kfar Saba · NCT06206759

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Propofol-triggered high triglycerides: understanding causes and guiding care

  This project looks at why propofol can raise triglycerides and how we can predict, monitor, and manage it to keep patients safer.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11447119

• Understanding different types of insulin resistance and their effects on triglyceride levels

  This study is looking at how insulin resistance affects triglyceride levels in different people, with the goal of finding personalized treatments that work best for each individual.

  NIH research Yale University · New Haven, United States · NIH-10800703

Related topics

Quick answers

How many Hypertriglyceridemia clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (6 trials), Australia (3 trials), Canada (3 trials), United Kingdom (2 trials), New Zealand (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 2, Phase 1/2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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