How disturbed blood flow and high cholesterol affect artery cells
Official title: Arterial Cell Reprogramming by Disturbed Flow and Hypercholesterolemia
Funded at Emory University · NIH-10998460 · Data updated 2026-11-12
This study is looking at how problems with blood flow and high cholesterol can lead to heart issues, using mice to learn more about how these factors affect tiny cells in our blood vessels, with the hope of finding new ways to prevent or treat atherosclerosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL176148-01 |
| Project ID | NIH-10998460 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with risk factors for atherosclerosis, such as high cholesterol or a family history of cardiovascular disease.
✕Less likely to help
Patients who do not have risk factors for atherosclerosis or those with advanced cardiovascular disease may not benefit from this research.
What this research studies
This research investigates how disturbed blood flow and high cholesterol levels contribute to the development of atherosclerosis, a condition that leads to serious cardiovascular diseases. By using a mouse model, the researchers aim to understand the mechanisms that cause endothelial cells to change in response to these conditions. They will employ advanced techniques like single-cell RNA sequencing to analyze how these changes occur at a cellular level. The goal is to identify new therapeutic targets that could help prevent or treat atherosclerosis more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse atherosclerosis, potentially reducing the risk of heart attacks and strokes.
How similar studies have gone: Previous studies have shown that targeting endothelial cell behavior can be effective in managing atherosclerosis, suggesting that this approach has potential for success.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Park, Christian — Emory University
- Study coordinator: Park, Christian
Related research
Other NIH-funded projects on the same topics.
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Using behavioral nudges to improve family screening for inherited high cholesterol
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-
Improving Risk Stratification for Familial Hypercholesterolemia (FH)
A patient-facing look at a study that aims to better predict who with familial hypercholesterolemia is at highest risk for early heart disease.
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Nonviral CRISPR-Cas9 delivery to liver cells to treat familial hypercholesterolemia
A new approach uses nonviral methods to deliver CRISPR-Cas9 to liver cells and select edited cells with acetaminophen, aiming to permanently lower bad cholesterol in people with familial hypercholesterolemia.
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A program to help people who donate blood and have familial hypercholesterolemia get the cholesterol-lowering treatment they need through a blood-donation center.
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Helping families find and treat inherited high cholesterol
This project tests a clinic-based program to help primary care doctors find and treat children and adults with inherited high cholesterol (familial hypercholesterolemia).
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Familial hypercholesterolemia: closing gaps in prevention of heart disease
A new NIH grant is exploring why people with familial hypercholesterolemia often go undiagnosed or receive uneven care, with the goal of improving early detection and prevention of heart disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.