How disturbed blood flow and high cholesterol affect artery cells
Arterial Cell Reprogramming by Disturbed Flow and Hypercholesterolemia
This study is looking at how problems with blood flow and high cholesterol can lead to heart issues, using mice to learn more about how these factors affect tiny cells in our blood vessels, with the hope of finding new ways to prevent or treat atherosclerosis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10998460 on NIH RePORTER |
What this research studies
This research investigates how disturbed blood flow and high cholesterol levels contribute to the development of atherosclerosis, a condition that leads to serious cardiovascular diseases. By using a mouse model, the researchers aim to understand the mechanisms that cause endothelial cells to change in response to these conditions. They will employ advanced techniques like single-cell RNA sequencing to analyze how these changes occur at a cellular level. The goal is to identify new therapeutic targets that could help prevent or treat atherosclerosis more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with risk factors for atherosclerosis, such as high cholesterol or a family history of cardiovascular disease.
Not a fit: Patients who do not have risk factors for atherosclerosis or those with advanced cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse atherosclerosis, potentially reducing the risk of heart attacks and strokes.
How similar studies have performed: Previous studies have shown that targeting endothelial cell behavior can be effective in managing atherosclerosis, suggesting that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Park, Christian — Emory University
- Study coordinator: Park, Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.