Condition

Hereditary Spastic Paraplegia clinical trials and research

• 15Clinical trials
• 10NIH research projects
• 12Countries

Newest Hereditary Spastic Paraplegia clinical trials

All recruiting trials (15)

• Rare Disease Registry for Movement Disorders in Southern Anhui

  This project is creating a registry to collect information from adults with motor neuron diseases, spinocerebellar ataxias, hereditary muscular dystrophy, or hereditary spastic paraplegia in Southern Anhui.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07838883

• TreatHSP/SPAX: An adaptive natural history platform for SPAX diseases

  This study tests a shared, long-term framework to track how SPAX diseases progress and to develop useful patient-centered outcome measures and biomarkers.

  Recruiting at 30 sites Heidelberg University · Innsbruck and 29 other locations · NCT07798674

• Noninvasive spinal stimulation to improve walking in hereditary spastic paraplegia

  This trial will test whether noninvasive transcutaneous spinal cord stimulation can improve walking and reduce muscle stiffness in adults with hereditary spastic paraplegia.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07417943

• Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

  This project uses a wrist/ankle wearable to continuously monitor walking and upper-limb movement in ambulant adults with neuromuscular diseases or obesity to see if digital measures like stride speed track real-life motor function.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège · NCT07136844

• Evaluating surgical treatment for foot deformities in hereditary spastic paraplegia

  This study is testing how well surgery can help people with hereditary spastic paraplegia and foot deformities feel and function better over two years.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06936163

• Exploring intrathecal baclofen treatment for hereditary spastic paraplegia

  This study is testing if a special pump that delivers baclofen directly into the spine can help people with hereditary spastic paraplegia improve their movement and quality of life better than taking the medication by mouth.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06844734

• Robot-assisted walking treatment for hereditary spastic paraplegia

  This study is testing whether using a robot to help with walking, along with regular physical therapy, can improve movement and quality of life for people with hereditary spastic paraplegia.

  Recruiting IRCCS Eugenio Medea · Bosisio Parini, Italy/lecco · NCT06728787

• Registry for Hereditary Spastic Paraplegia to Support Future Treatments

  This study is creating a database to track people with hereditary spastic paraplegia over time to help understand the condition better and support future treatments.

  Recruiting IRCCS Fondazione Stella Maris · Pisa · NCT06572046

• Research network for hereditary spastic paraplegia and primary lateral sclerosis

  This study is trying to learn more about hereditary spastic paraplegia and primary lateral sclerosis by enrolling people with specific types of the condition to help find better treatments and understand how these diseases progress.

  Recruiting Boston Children's Hospital · Miami, Florida and 10 other locations · NCT06553976

• Calcium folinate treatment for hereditary spastic paraplegia SPG56

  This study is testing if calcium folinate can help people with hereditary spastic paraplegia type 56 feel better over a six-year period.

  Recruiting Early Phase 1 Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06478238

• Observing the natural history of patients with HPDL mutations

  This study is trying to learn more about people with HPDL mutations and their related mitochondrial diseases by collecting health information and blood samples to see how these conditions change over time.

  Recruiting University of California, San Diego · San Diego, California · NCT05848271

• Genetic analysis of hereditary spastic paraplegia

  This study is trying to find out the genetic causes of hereditary spastic paraplegia to help improve diagnosis and treatment for people living with this condition.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05354622

• Registry for Early Onset Hereditary Spastic Paraplegia

  This study is collecting information and samples from people under 30 with early onset hereditary spastic paraplegia to help understand the condition better and find new treatments.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04712812

• Understanding Hereditary Spastic Paraplegias and Related Disorders

  This study is trying to learn more about Hereditary Spastic Paraplegias and related disorders by following patients over time and looking at their symptoms, genetics, and potential treatments.

  Recruiting at 8 sites University Hospital Tuebingen · Innsbruck and 12 other locations · NCT03981276

• Studying early signs of hereditary spastic paraplegia in at-risk individuals

  This study is trying to find early signs of hereditary spastic paraplegia in people who might be at risk, to better understand how the disease develops before symptoms show up.

  Recruiting University Hospital Tuebingen · Tübingen · NCT03206190

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding axon degeneration in hereditary spastic paraplegia and ALS using patient-derived neurons

  Aimed at understanding why certain nerve fibers die in hereditary spastic paraplegia and ALS by studying neurons made from patients’ own stem cells.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11528579

• Combinatorial Therapy for SPG4 hereditary spastic paraplegia

  Aims to test gene-based treatments to help people with SPG4-related hereditary spastic paraplegia manage mobility and related symptoms.

  NIH research Drexel University · Philadelphia, United States · NIH-11450314

• Understanding how full-length spastin works and its role in hereditary spastic paraplegia

  This grant aims to uncover how the spastin protein uses ATP to cut and regrow microtubules, shedding light on the most common inherited cause of a neurodegenerative leg-weakness disorder.

  NIH research Yale University · New Haven, United States · NIH-11437995

• Finding hidden genetic causes of hereditary spastic paraplegia

  Using whole genome sequencing to find genetic causes for people with hereditary spastic paraplegia whose earlier genetic tests came up inconclusive.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11401447

• A new antibody-based therapy for SPG4 hereditary spastic paraplegia

  A small NIH grant is funding a therapy aimed at reducing mutant M1 spastin protein to help people with SPG4-HSP, a gradual leg-weakening neurodegenerative condition.

  NIH research Drexel University · Philadelphia, United States · NIH-11388925

• Understanding nerve damage in hereditary spastic paraplegia

  Researchers are using genetically modified rats and patient-derived stem cells to learn how gene mutations cause nerve fiber damage in people with hereditary spastic paraplegia.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11324245

• Understanding and treating a genetic condition that affects movement in children

  This study is looking at how certain genes affect movement problems in children with hereditary spastic paraplegia and is testing new treatments that might help improve their nerve function and overall health.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11083563

• Understanding nerve damage in hereditary spastic paraplegia

  This study is looking into how genetic changes cause nerve damage in hereditary spastic paraplegia (HSP), which affects balance and muscle strength, with the hope of finding new treatments to help people with this condition.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11061852

• Understanding the causes of hereditary spastic paraplegia

  This study is looking at how changes in a specific gene related to hereditary spastic paraplegia can harm nerve cells, with the hope of finding better treatments for people living with this condition.

  NIH research Drexel University · Philadelphia, United States · NIH-10991380

• Understanding the causes of SPG4 Hereditary Spastic Paraplegia

  This study is looking into how changes in the SPAST gene cause problems in the nerves for people with SPG4 Hereditary Spastic Paraplegia, with the hope of finding new ways to help those affected by this condition.

  NIH research Drexel University · Philadelphia, United States · NIH-10892167

Related topics

Quick answers

How many Hereditary Spastic Paraplegia clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (5 trials), Italy (4 trials), China (4 trials), Germany (3 trials), Austria (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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