Condition

Myotonic Dystrophy 1 clinical trials and research

• 10Clinical trials
• 17Countries

Newest Myotonic Dystrophy 1 clinical trials

All recruiting trials (10)

• Understanding long-term progression in myotonic dystrophy type 1 (DM1)

  This study will follow adults with DM1 for at least four years to see how walking, hand function, muscle strength, heart rhythms, and lung function change over time.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07700225

• Spanish National Registry for Myotonic Dystrophy Type 1

  This registry gathers health, clinical, and genetic information from people in Spain with DM1 to see how the condition changes over time and help match patients to future trials.

  Recruiting at 8 sites Fundació Institut Germans Trias i Pujol · Multiple Locations, Andalusia and 7 other locations · NCT07385443

• Long-term PGN-EDODM1 extension for people with myotonic dystrophy type 1

  This open-label extension will try continued PGN-EDODM1 in people with myotonic dystrophy type 1 who completed a prior PGN-EDODM1 study to see how safe and tolerable it is over time.

  Recruiting at 3 sites Phase 2 PepGen Inc · Calgary, Alberta and 2 other locations · NCT07220603

• Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

  This project uses a wrist/ankle wearable to continuously monitor walking and upper-limb movement in ambulant adults with neuromuscular diseases or obesity to see if digital measures like stride speed track real-life motor function.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège · NCT07136844

• Investigating PGN-EDODM1 for Myotonic Dystrophy Type 1

  This study is testing a new medication called PGN-EDODM1 to see if it is safe and well-tolerated in people with myotonic dystrophy type 1.

  Recruiting at 12 sites Phase 2 PepGen Inc · Calgary, Alberta and 11 other locations · NCT06667453

• Testing ATX-01 for myotonic dystrophy type 1

  This study is testing a new drug called ATX-01 to see if it is safe and well-tolerated in people with myotonic dystrophy type 1.

  Recruiting at 12 sites Phase 1/2 ARTHEx Biotech S.L. · Los Angeles, California and 11 other locations · NCT06300307

• Collecting data on muscle disorders using wearable devices

  This study is testing a wearable device to track movement in people with muscle disorders like Duchenne Muscular Dystrophy and Myotonic Dystrophy to see how it can help improve their care.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Liege · Liège and 7 other locations · NCT05982119

• Metformin to improve muscle strength in myotonic dystrophy type 1

  This will test whether taking metformin can improve muscle strength and daily function in adults with myotonic dystrophy type 1 who can still walk.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Garches · NCT05532813

• Identifying biomarkers and clinical endpoints in Myotonic Dystrophy Type 1

  This study is trying to learn more about Myotonic Dystrophy Type 1 by looking at how the disease affects around 700 adults over two years, including their muscle health and daily activities.

  Recruiting at 15 sites Virginia Commonwealth University · La Jolla, California and 16 other locations · NCT03981575

• Online registry for myotonic dystrophy patients

  This study is creating an online registry for people with myotonic dystrophy to share their experiences and help researchers find better treatments.

  Recruiting Myotonic Dystrophy Foundation · Oakland, California · NCT02398786

Related topics

Quick answers

How many Myotonic Dystrophy 1 clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (4 trials), Canada (4 trials), United Kingdom (3 trials), New Zealand (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →