Condition

Neonatal Encephalopathy clinical trials and research

• 14Clinical trials
• 5NIH research projects
• 10Countries

Newest Neonatal Encephalopathy clinical trials

All recruiting trials (14)

• Newborn Brain Wave Checker: See if CergenX Wave matches the Sarnat exam

  This study tests whether the CergenX Wave software, which analyzes a newborn's EEG via a small four-electrode setup, can match the standard Sarnat examination in babies with suspected neonatal encephalopathy.

  Recruiting CergenX Limited · Dallas, Texas and 1 other locations · NCT07857070

• Neonatal Neurological Observation With Video AI

  This study tests a real-time, non-contact video AI system to help monitor brain health in newborns with suspected brain injury during their hospital stay.

  Recruiting Artemis AI Labs · New York, New York and 1 other locations · NCT07628829

• Genetic causes of neonatal encephalopathy and related conditions

  This project will see if DNA changes help explain neonatal encephalopathy in children under 6 who receive care at Boston Children's Hospital.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT07165938

• Using breast milk to treat brain injury in newborns

  This study is testing if giving breast milk through the nose can help newborns with brain injuries feel better and develop normally while they are being treated with cooling therapy.

  Recruiting Early Phase 1 Semmelweis University · Budapest · NCT06747260

• Using intranasal breast milk to improve outcomes in newborns with brain injury

  This study is testing if giving fresh breast milk through the nose can help newborns with brain injury do better in the long run compared to standard care.

  Recruiting Early Phase 1 Semmelweis University · Budapest · NCT06746532

• Using sildenafil to treat brain injury in newborns after asphyxia

  This study is testing if sildenafil can help newborns with brain injuries from lack of oxygen at birth recover better after treatment with cooling therapy.

  Recruiting at 3 sites Phase 2 McGill University Health Centre/Research Institute of the McGill University Health Centre · Denver, Colorado and 2 other locations · NCT06098833

• Investigating eye function in babies with brain injury

  This study is trying to see how eye function in babies with brain injuries affects their development over time.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT05971446

• Whole-body cooling for babies with mild neonatal encephalopathy

  This trial will test whether lowering body temperature soon after birth helps newborns with mild hypoxic‑ischaemic encephalopathy have better development by age two.

  Recruiting at 39 sites Phase 3 Imperial College London · Naples and 38 other locations · NCT05889507

• Observing the natural history of patients with HPDL mutations

  This study is trying to learn more about people with HPDL mutations and their related mitochondrial diseases by collecting health information and blood samples to see how these conditions change over time.

  Recruiting University of California, San Diego · San Diego, California · NCT05848271

• Testing Levetiracetam for treating neonatal seizures

  This study is testing how much of the medication Levetiracetam is safe to give to newborns with seizures to see if it works better than the standard treatment.

  Recruiting at 5 sites Phase 2 University of California, San Diego · San Diego, California and 5 other locations · NCT05610085

• Evaluating Sovateltide for treating brain injury in newborns

  This study is testing a new treatment called Sovateltide to see if it can help newborns with brain injuries caused by lack of oxygen during birth.

  Recruiting at 2 sites Phase 2 Pharmazz, Inc. · Mangalore, Karnataka and 3 other locations · NCT05514340

• Newborn brain activity and oxygen monitoring immediately after birth

  This trial will test whether a single scalp sensor that records EEG and near-infrared oxymetry can track full-term newborns' brain electrical activity and oxygen levels during the first 15 minutes after birth.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT04225975

• Monitoring brain health in newborns at risk of brain injuries

  This study is testing a new device to monitor brain health in newborns at risk of brain injuries to see how oxygen levels affect their recovery during their hospital stay.

  Recruiting Boston Children's Hospital · Boston, Massachusetts and 2 other locations · NCT02793999

• Creating a neonatal neurologic data center in China

  This study is setting up a network in China to gather important health information and samples from newborns with severe brain issues to help doctors predict problems and find better treatments.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT02544100

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Hydrogen therapy for newborns with brain injury

  A new NICU trial will test inhaled hydrogen added to standard hypothermia therapy to see if it can improve survival and brain outcomes for babies with hypoxic-ischemic brain injury.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11341428

• MRI markers to predict outcomes after newborn brain injury

  This project uses newborn brain MRI scans and AI tools to help doctors predict which babies with oxygen-related brain injury may have developmental problems by 18–22 months.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11336387

• Real-time brain blood-flow and oxygen monitoring for newborns with birth-related brain injury

  This project uses a bedside monitoring system that tracks brain blood flow and oxygen in newborns with suspected oxygen-related injury to help doctors spot damage early.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11324991

• Using MRI to identify brain injury in newborns with hypoxic ischemic encephalopathy

  This study is looking for better ways to check for brain injuries in newborns with hypoxic ischemic encephalopathy (HIE) so that doctors can spot problems earlier and find the best treatments for these babies.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11134770

• Effects of blood sugar levels on brain health in newborns with brain injury

  This study looks at how high blood sugar levels can impact the brains of newborns with a condition called hypoxic-ischemic encephalopathy (HIE), and it aims to help parents understand how these early sugar levels might affect their child's development as they grow.

  NIH research Hospital for Sick Chldrn (Toronto) · Toronto, Canada · NIH-10844559

Related topics

Quick answers

How many Neonatal Encephalopathy clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (8 trials), Hungary (2 trials), Italy (1 trial), United Kingdom (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Early Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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