Robot-assisted walking treatment for hereditary spastic paraplegia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of a combined rehabilitation approach using the Lokomat robotic gait training system alongside traditional physical therapy for patients with hereditary spastic paraplegia (HSP). Participants will undergo a total of 30 sessions over three weeks, with assessments conducted before, after treatment, and at a three-month follow-up. The study aims to measure improvements in gait, functional abilities, and quality of life through various clinical-functional assessments. This approach seeks to enhance the rehabilitation experience and outcomes for individuals affected by this rare neurological disorder.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* genetic or clinical diagnosis of HSP.
* age greater than 4 years and less than 70
* femur length \> 23 cm
* ability to walk independently indoors, with or without walking aids.

Exclusion Criteria:

* botulinum toxin injection or lower limb surgery in the previous 6 months
* severe lower limb muscle retractions
* severe osteoporosis
* unhealed skin lesions in lower limbs
* cardiovascular instability
* acute or progressive neurological disorders
* behavioral problemS

Where it's running

• Irccs Eugenio Medea
  Bosisio Parini, Italy/lecco, Italy Recruiting

Study contacts

• Study coordinator: Eleonora Diella
• Email: eleonora.diella@lanostrafamiglia.it
• Phone: 3286859456

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Rare Disease Registry for Movement Disorders in Southern Anhui

  This project is creating a registry to collect information from adults with motor neuron diseases, spinocerebellar ataxias, hereditary muscular dystrophy, or hereditary spastic paraplegia in Southern Anhui.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07838883

• TreatHSP/SPAX: An adaptive natural history platform for SPAX diseases

  This study tests a shared, long-term framework to track how SPAX diseases progress and to develop useful patient-centered outcome measures and biomarkers.

  Recruiting at 30 sites Heidelberg University · Innsbruck and 29 other locations · NCT07798674

• Noninvasive spinal stimulation to improve walking in hereditary spastic paraplegia

  This trial will test whether noninvasive transcutaneous spinal cord stimulation can improve walking and reduce muscle stiffness in adults with hereditary spastic paraplegia.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07417943

• Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

  This project uses a wrist/ankle wearable to continuously monitor walking and upper-limb movement in ambulant adults with neuromuscular diseases or obesity to see if digital measures like stride speed track real-life motor function.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège · NCT07136844

• Evaluating surgical treatment for foot deformities in hereditary spastic paraplegia

  This study is testing how well surgery can help people with hereditary spastic paraplegia and foot deformities feel and function better over two years.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06936163

• Exploring intrathecal baclofen treatment for hereditary spastic paraplegia

  This study is testing if a special pump that delivers baclofen directly into the spine can help people with hereditary spastic paraplegia improve their movement and quality of life better than taking the medication by mouth.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06844734

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.