Understanding the causes of hereditary spastic paraplegia
Elucidating the etiology of SPAST-based Hereditary Spastic Paraplegia
This study is looking at how changes in a specific gene related to hereditary spastic paraplegia can harm nerve cells, with the hope of finding better treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10991380 on NIH RePORTER |
What this research studies
This research investigates hereditary spastic paraplegia (HSP), a neurodegenerative disorder that leads to progressive weakness and spasticity in the lower limbs. The study focuses on the SPAST gene, which is commonly mutated in HSP, and aims to explore the toxic effects of mutant spastin proteins on nerve cells. By using advanced mouse models, researchers will examine how these mutations contribute to the degeneration of specific nerve pathways, which could lead to better understanding and potential treatments for patients with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hereditary spastic paraplegia, particularly those with mutations in the SPAST gene.
Not a fit: Patients with hereditary spastic paraplegia caused by mutations in genes other than SPAST may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or treating hereditary spastic paraplegia.
How similar studies have performed: Previous research has shown promise in understanding neurodegenerative disorders through genetic and molecular approaches, suggesting potential for success in this area.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Qiang, Liang — Drexel University
- Study coordinator: Qiang, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.