Studying early signs of hereditary spastic paraplegia in at-risk individuals

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to collect prospective longitudinal data on the natural progression of hereditary spastic paraplegia type 4 (SPG4) in presymptomatic mutation carriers and those in the early stages of the disease. It will utilize various interventions, including clinical assessments, cognitive testing, lumbar punctures, blood draws, MRI scans, and electrophysiological evaluations to identify biomarkers that provide objective measures of disease activity. The goal is to better understand the disease before clinical symptoms appear and to track its early progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* First degree relatives (parents, offspring, and sibs) of SPG4 patients or symptomatic individuals with known SPAST mutation
* Age 18 to 70 years
* Written, informed consent (patient)

Exclusion Criteria:

* No known SPAST-mutation within the family
* Manifest spastic gait (subclinical signs like increased deep tendon reflexes, positive Babinski sign are allowed)
* Participation in interventional trials

Where it's running

• University Hospital Tübingen, Center for Neurology
  Tübingen, Germany Recruiting

Study contacts

• Principal investigator: Ludger Schöls, Prof. — Head of Department
• Study coordinator: Ludger Schöls, Prof.
• Email: ludger.schoels@uni-tuebingen.de
• Phone: +49 7071 / 29

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Rare Disease Registry for Movement Disorders in Southern Anhui

  This project is creating a registry to collect information from adults with motor neuron diseases, spinocerebellar ataxias, hereditary muscular dystrophy, or hereditary spastic paraplegia in Southern Anhui.

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• TreatHSP/SPAX: An adaptive natural history platform for SPAX diseases

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• Noninvasive spinal stimulation to improve walking in hereditary spastic paraplegia

  This trial will test whether noninvasive transcutaneous spinal cord stimulation can improve walking and reduce muscle stiffness in adults with hereditary spastic paraplegia.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT07417943

• Wearable monitoring of walking and arm movement in adults with neuromuscular or metabolic movement disorders

  This project uses a wrist/ankle wearable to continuously monitor walking and upper-limb movement in ambulant adults with neuromuscular diseases or obesity to see if digital measures like stride speed track real-life motor function.

  Recruiting Centre Hospitalier Universitaire de Liege · Liège · NCT07136844

• Evaluating surgical treatment for foot deformities in hereditary spastic paraplegia

  This study is testing how well surgery can help people with hereditary spastic paraplegia and foot deformities feel and function better over two years.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06936163

• Exploring intrathecal baclofen treatment for hereditary spastic paraplegia

  This study is testing if a special pump that delivers baclofen directly into the spine can help people with hereditary spastic paraplegia improve their movement and quality of life better than taking the medication by mouth.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06844734

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.