Condition

Clostridium Difficile Infection clinical trials and research

• 10Clinical trials
• 3NIH research projects
• 6Countries

Newest Clostridium Difficile Infection clinical trials

All recruiting trials (10)

• Orally ingested yeast designed to express a tetra-specific anti-toxin for Clostridioides difficile safety study

  This first-in-human trial tests a yeast-based medicine (FZ002) to see if it is safe and tolerable for adults with no active infection, using a placebo for comparison.

  Recruiting Phase 1 National Institute of Allergy and Infectious Diseases (NIAID) · Knoxville, Tennessee · NCT07649096

• Oral vancomycin to prevent C. difficile infection in critically ill adults

  This trial sees if taking oral vancomycin can prevent C. difficile infection in critically ill adults who are receiving systemic antibiotics.

  Recruiting Phase 2/3 Riverside University Health System Medical Center · Moreno Valley, California · NCT07221370

• Investigating Clostridium Difficile Infection in Infants

  This study looks at how common Clostridium difficile infections are in infants and what factors might increase the risk, to help improve diagnosis and treatment for these young patients.

  Recruiting First People's Hospital of Hangzhou · Hangzhou, Zhejiang, China · NCT06703918

• Investigating factors related to Clostridioides difficile infection recurrence

  This study is trying to find out how certain body factors, like gut bacteria and genetics, affect the chances of Clostridioides difficile infection coming back in adults who have already been diagnosed with it.

  Recruiting at 12 sites Hospital Universitario de Valme · Alicante, Alicante and 14 other locations · NCT04801862

• Using alanyl-glutamine to treat C. difficile infections

  This study is testing if taking alanyl-glutamine can help people with C. difficile infections recover better and prevent the infection from coming back.

  Recruiting at 2 sites Phase 2 University of Virginia · Charlottesville, Virginia and 1 other locations · NCT04305769

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Fecal Transplant for Clostridioides difficile Infection

  This project tests fecal microbiota transplantation for adults with Clostridioides difficile infection to see if it helps treat the illness.

  Recruiting University of Aarhus · Aarhus N · NCT03712722

• Fecal microbiota transplantation for treating recurrent C. difficile infections

  This study is testing whether a stool transplant from a healthy donor can help people with repeated C. difficile infections feel better compared to regular antibiotic treatments.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT03562741

• National registry for fecal microbiota transplantation

  This study is collecting information from 4,000 patients who are getting fecal microbiota transplants to see how well the treatment works and what effects it has over time.

  Recruiting at 26 sites American Gastroenterological Association · Phoenix, Arizona and 52 other locations · NCT03325855

• Fecal Microbiota Transplantation for Clostridium Difficile Infection

  This study is testing if a treatment using healthy bacteria from a donor's stool can help people with recurring Clostridium difficile infections feel better.

  Recruiting Englewood Hospital and Medical Center · Englewood, New Jersey · NCT01905709

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How new antibiotic resistance in C. difficile affects treatment

  This project looks at how recent changes that make C. difficile resistant to metronidazole and vancomycin could affect people with C. difficile infections.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11262328

• Understanding how metronidazole resistance affects Clostridium difficile infections.

  This study is looking into why some Clostridium difficile infections don't respond to a common treatment called metronidazole, and it aims to help patients by figuring out how these resistant strains work so doctors can find better ways to treat them.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11014389

• Investigating Clostridium difficile infections in patients with inflammatory bowel disease

  This study is looking at how Clostridium difficile infections can impact people with inflammatory bowel disease, aiming to find out why these infections happen more often and come back in these patients, so we can improve their treatment and care.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10774228

Related topics

Quick answers

How many Clostridium Difficile Infection clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (6 trials), Hong Kong (1 trial), Spain (1 trial), Denmark (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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