Condition

Fracture clinical trials and research

• 15Clinical trials
• 129NIH research projects
• 2New in 30 days
• 12Countries

Newest Fracture clinical trials

All recruiting trials (15)

• See if a new tomosynthesis imaging tool helps diagnose MSK issues in ED and clinic

  This study tests whether the Nanox.ARC Digital Tomosynthesis system can add diagnostic value for adults with suspected MSK problems and potentially reduce the need for CT or MRI.

  Recruiting Nano-X Imaging · Kfar Saba · NCT07900412

• REMS testing for osteoporosis diagnosis and fracture risk in adults compared with DXA

  This study tests whether REMS can diagnose osteoporosis and predict fracture risk in adults who are being evaluated for bone health, using DXA as the standard reference.

  Recruiting at 2 sites BoneVue Diagnostics · Easton, Maryland and 1 other locations · NCT07876882

• See how well iFuse TORQ TNT works for pelvic fragility fractures

  This study tests the iFuse TORQ TNT implant in older adults with pelvic fragility fractures to see if real-world use leads to better outcomes.

  Recruiting at 3 sites SI-BONE, Inc. · Edina, Minnesota and 2 other locations · NCT07530497

• Buprenorphine for pain relief in older adults with broken bones in the ED

  This study tests whether buprenorphine can safely and effectively relieve pain in older adults with acute fractures, compared with hydromorphone.

  Recruiting Phase 1/2 Cooper Norcross Health · Camden, New Jersey · NCT07430345

• Cannabidiol for pain relief after traumatic fractures and to reduce opioid use

  We will test whether taking cannabidiol twice daily for one month can reduce pain and opioid use in adults 18–70 treated for recent long-bone fractures at Sacré-Coeur Hospital.

  Recruiting Phase 2 Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Montreal, Quebec · NCT06448923

• Observing outcomes of the Medacta Shoulder System

  This study is looking at how well the Medacta Shoulder System works and its safety for people with different shoulder problems.

  Recruiting Medacta International SA · Annecy · NCT05926622

• Comparing oral and intravenous antibiotics for treating infected nonunion of fractures

  This study is testing whether taking antibiotics by mouth works as well as getting them through an IV for people with infected fractures that haven't healed properly after surgery.

  Recruiting at 9 sites Phase 3 Major Extremity Trauma Research Consortium · Indianapolis, Indiana and 12 other locations · NCT05699174

• Long-term follow-up on shoulder arthroplasty outcomes

  This study is looking at how well shoulder replacement surgery works over time by following patients for at least 10 years to see how they feel and how their shoulders are doing.

  Recruiting at 40 sites Exactech · Laguna Woods, California and 39 other locations · NCT05603728

• Evaluating the safety and effectiveness of pediatric orthopedic implants

  This study is testing how safe and effective orthopedic implants are for kids with fractures and limb deformities to see how they perform over time.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT05361980

• Single-dose IV iron for anemia after orthopedic fracture surgery

  This trial will test whether a single intravenous iron infusion helps adults (18–89) with anemia after lower-extremity or pelvic fracture surgery recover with fewer complications and less fatigue.

  Recruiting Phase 4 Oregon Health and Science University · Portland, Oregon · NCT05292001

• Comparing surgical and non-surgical treatment for rib fractures

  This study is testing whether a new surgical method for fixing rib fractures works better than regular pain management for people with non-flail chest rib fractures.

  Recruiting at 4 sites Zimmer Biomet · Sydney, New South Wales and 4 other locations · NCT05146986

• Assessing strength recovery after elbow fractures in elderly patients

  This study looks at how well elderly patients recover strength and function after elbow fractures, comparing different treatment methods over a year.

  Recruiting Fraser Orthopaedic Research Society · New Westminster, British Columbia · NCT05135949

• Evaluating the performance of new clavicle plates for fractures and dislocations

  This study is testing a new type of plate for fixing broken collarbones to see how well it works and how safe it is for patients over two years after surgery.

  Recruiting at 7 sites AO Innovation Translation Center · Grand Rapids, Michigan and 6 other locations · NCT04921865

• Using intranasal dexmedetomidine and ketamine for sedation in children with fractures

  This study is testing a new way to help kids aged 2-17 feel calm and comfortable during treatment for fractures by using a nasal spray instead of an IV.

  Recruiting Phase 2/3 London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Edmonton, Alberta and 5 other locations · NCT04195256

• Fracture liaison and osteoporosis medication monitoring program at National Taiwan University Hospital

  This program tests whether a coordinated fracture liaison service plus a medication-monitoring service can help people aged 50+ with recent hip or spine fractures or on osteoporosis drugs stick with treatment and get appropriate follow-up.

  Recruiting National Taiwan University Hospital · Hsinchu · NCT02635022

NIH-funded research (newest 40 of 129)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Adenosine-based help to speed up bone fracture healing in older adults

  A biomaterial-based approach delivers adenosine locally to fractures to speed healing in aging bones.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11591716

• Role of Schwann Cell Precursors in Fracture Healing

  This NIH grant explores how a specific nerve-support cell type called Schwann cell precursors may influence bone healing and pain after fractures, using mouse models to map how these cells behave during healing.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11449905

• Longitudinal imaging to predict bone fracture healing using light-based tech

  Aims to use safe light-based imaging over time to see how healing bones in people with fractures progress and whether early signals predict problems.

  NIH research University of Rochester · Rochester, United States · NIH-11449366

• Rejuvenating B cells to help older people heal broken bones

  Aims to boost aged B cells to improve how bone heals after fractures in older patients.

  NIH research Duke University · Durham, United States · NIH-11436913

• Intermittent Fasting to Boost Fracture Healing in Obesity and Type 2 Diabetes

  A study tests whether intermittent fasting can improve bone healing in people with obesity and type 2 diabetes by changing the gut microbiome.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11434069

• Next-Generation MRI to Predict Bone Healing Using Virtual Testing

  A new MRI-based method uses advanced imaging and computer models to predict how well broken bones are healing, starting with shinbone (tibial) fractures.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11421412

• Urine cadmium and bone health in older adults

  This project looks at whether long-term cadmium exposure, measured in urine, is linked to bone loss and fractures in older adults.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11420047

• Predicting lower-leg fracture risk during exoskeleton-assisted walking after spinal cord injury

  This project uses scans and movement data to predict which people with recent spinal cord injuries might have a higher risk of leg fractures when walking with a robotic exoskeleton.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11418692

• Boosting bone metabolism to speed fracture healing in diabetes

  Seeing if raising a molecule called NAMPT in broken bones helps people with obesity-related type 2 diabetes heal fractures faster.

  NIH research VA Loma Linda Healthcare System · Loma Linda, United States · NIH-11415402

• Therapeutic use of 3D-printed scaffolds and small-molecule activators to heal bone fractures in CKD mice

  A bone-healing strategy using 3D-printed scaffolds and two small molecules aims to improve fracture healing in a mouse model of chronic kidney disease.

  NIH research VA Loma Linda Healthcare System · Loma Linda, United States · NIH-11413002

• Improving Fracture Healing with Active Plating Technology

  A new plate technology aims to fix broken bones in adults more reliably by providing controlled motion at the fracture to speed healing, especially in those with osteoporosis.

  NIH research Apex Biomedical Company, LLC · Wilsonville, UNITED STATES · NIH-11405527

• FRAX fracture risk in rheumatoid arthritis patients 65 and older

  This grant tests how well the FRAX fracture risk tool predicts fractures in people with rheumatoid arthritis who are 65 and older.

  NIH research Augusta University · Augusta, United States · NIH-11404833

• MAC-STILA: Safer, gentler anesthesia for hip fracture in older adults

  A multi-center trial tests a new anesthesia approach (MAC-STILA) to reduce delirium and other problems after hip-fracture surgery in older adults with dementia.

  NIH research New York University School of Medicine · New York, United States · NIH-11399101

• Using wearables to improve recovery after tibial fracture surgery

  A wearable-enabled study will track tibial bone forces in people recovering from tibia surgery to help tailor rehab and improve long-term function.

  NIH research University of Kentucky · Lexington, United States · NIH-11389508

• Mechanisms of bone loss after a fracture

  A study at UC San Francisco will look at why bones elsewhere in the body lose mass after a fracture by analyzing blood to find biological clues.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11386666

• HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury

  A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11382759

• New approaches to fracture healing and bone pain relief

  A study in mice tests a new way to help bone healing after fracture while reducing bone-pain without relying on opioids.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11377544

• Immunomodulation after polytrauma to help bone healing

  This NIH grant explores how inflammation and immune signals affect bone healing after severe injuries in adults to improve recovery.

  NIH research University of California at Davis · Davis, United States · NIH-11374937

• Understanding how specific immune cells affect bone fracture healing

  Aimed at figuring out why some broken bones scar or heal badly by studying a particular type of immune cell in bone under strain, with the goal of better healing therapies.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11373376

• Painless nerve growth factor to speed bone fracture healing

  This project tests an injectable, biodegradable nanowire that slowly releases a painless form of nerve growth factor to help people with hard-to-heal long-bone fractures mend faster.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11370459

• Systemic bone loss after fracture in humans

  This project tests how a fracture in people affects bone loss across the body over time, especially comparing younger and older adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11369808

• FSH hormone link to memory loss and bone fractures in older adults

  Researchers are looking at whether higher levels of the hormone FSH are connected to memory problems and weaker bones in older adults, especially postmenopausal women.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11365795

• Biomarkers and Imaging to Predict Fractures in Duchenne Muscular Dystrophy

  Researchers are testing biochemical and imaging markers to predict which people with Duchenne muscular dystrophy will have fractures, so doctors can prevent them.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11365265

• Real-time bone perfusion imaging to guide cleaning out infected bone

  A real-time imaging tool helps surgeons remove only the infected, poorly perfused bone during treatment of infections after fractures, aiming to improve healing and reduce the need for repeat surgeries.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11363874

• Somatosensory nerves help bones heal better

  This grant explores how sensory nerves and signaling molecules influence bone healing so people with fractures may have faster and better repair.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11340147

• Hox-Regulated MSCs and Bone Healing in Adults

  A study at the University of Wisconsin–Madison is exploring how Hox genes control bone growth and healing in adults, using special genetic tools to watch and modify bone stem cells.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11336929

• A new target to improve bone healing in older adults

  A Duke University team is testing whether lowering a blood protein called ApoE can help bones heal faster after fractures in older people.

  NIH research Duke University · Durham, United States · NIH-11326777

• Understanding recovery after hip fracture for older adults with dementia

  The team will build new data tools to better predict and explain recovery patterns after hip fracture for older adults living with Alzheimer’s disease and related dementias.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11325835

• Blood PFAS levels and bone loss in older adults

  This project will look at whether common environmental chemicals called PFAS in blood are linked to bone thinning and higher fracture risk in older adults.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11324617

• Robotic image-guided system to align broken femur (thigh) bones

  A surgical robot that uses 3D imaging to help surgeons precisely align broken thigh (femur) bones during repair.

  NIH research Rowan University · Glassboro, United States · NIH-11308194

• Blocking Siglec-15 to help bones heal and stay strong after spinal cord injury

  A treatment that blocks Siglec-15 aims to strengthen bones and improve fracture healing for people living with chronic spinal cord injury.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11306008

• Local adenosine treatment to reduce pain and help heal bone fractures

  This work is developing a local adenosine-based approach to relieve pain and support healing for people with bone fractures.

  NIH research Duke University · Durham, United States · NIH-11303603

• Hip fracture risk in people with chronic kidney disease

  A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11298380

• Modulation of Bone Formation and Fracture Repair in Cancer Patients

  This grant aims to understand how cancer and its treatments affect bone formation and fracture healing, with the goal of improving bone health for cancer survivors.

  NIH research Washington University · Saint Louis, United States · NIH-11297367

• Using MRI to understand and prevent atypical femoral fractures

  A health study to find MRI-based signs that predict atypical femoral fractures so doctors can tailor osteoporosis treatment and reduce dangerous breaks.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11295059

• Metastatic spine cancer care with a new injectable bone cement

  A Mayo Clinic research team is testing a new injectable cement to strengthen bones in people with cancer that has spread to the spine, aiming to prevent or repair fractures with less invasive treatment.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11294278

• Improving bone healing in obese individuals

  This study is looking at how being overweight affects the healing of broken bones, especially for people with diabetes, and it hopes to find ways to help improve recovery for those who struggle with this issue.

  NIH research Texas A&m Agrilife Research · College Station, UNITED STATES · NIH-11293189

• Improving fracture healing for people with diabetes

  Aiming to help bones heal better in people with diabetes by using a slow‑release gel that boosts bone cell signaling.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11285446

• How bones weaken in different ways that lead to hip fractures

  This project looks at how differences in bone size, mineral content, and bone area relate to hip fracture risk in older men and women.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11266228

• Helping broken bones heal by boosting Notch signaling

  Researchers aim to boost a natural cell signal called Notch to help people with large or slow-healing bone fractures recover faster.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11259514

Related topics

Quick answers

How many Fracture clinical trials are recruiting right now?

15, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (7 trials), Canada (5 trials), France (2 trials), Germany (2 trials), Taiwan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2/3: 1, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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