New approaches to fracture healing and bone pain relief
Official title: Novel treatments of fracture repair and bone pain
Funded at Indiana University Indianapolis · NIH-11377544 · Data updated 2026-11-12
A study in mice tests a new way to help bone healing after fracture while reducing bone-pain without relying on opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $581,734 |
| NIH project number | 5R01AR083130-03 |
| Project ID | NIH-11377544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with acute bone fractures in whom future translational therapies targeting CGRP pathways could be relevant.
✕Less likely to help
Patients without bone fractures or those not involving CGRP-related pathways may not benefit from this specific approach.
What this research studies
This project will use a mouse model of surgically induced femoral fracture to see how delivering CGRP affects bone healing and pain. It will also test whether a repurposed anti-CGRP antibody can lessen fracture-related pain without harming the healing process. The researchers aim to understand how CGRP signaling influences both recovery of bone and the experience of pain after fracture. Results could point to safer pain relief options that don’t hinder healing in the elderly after bone injuries.
Why it matters
Potential benefit: If successful, this work could lead to non-opioid pain treatments that support bone healing and reduce chronic pain after fractures.
How similar studies have gone: Preclinical studies have explored CGRP’s role in pain and bone biology, but this exact fracture-related CGRP modulation approach remains investigational.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: White, Fletcher a — Indiana University Indianapolis
- Study coordinator: White, Fletcher a
Related research
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Role of Schwann Cell Precursors in Fracture Healing
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Intermittent Fasting to Boost Fracture Healing in Obesity and Type 2 Diabetes
A study tests whether intermittent fasting can improve bone healing in people with obesity and type 2 diabetes by changing the gut microbiome.
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Next-Generation MRI to Predict Bone Healing Using Virtual Testing
A new MRI-based method uses advanced imaging and computer models to predict how well broken bones are healing, starting with shinbone (tibial) fractures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.