Therapeutic use of 3D-printed scaffolds and small-molecule activators to heal bone fractures in CKD mice
Official title: Therapeutic Evaluation of 3D-printed Scaffolds with Small Molecule Activators of IL17 and Wnt Signaling to Promote Healing of Clinically Relevant Trochanteric Fracture in Chronic Kidney Disease Mice
Funded at VA Loma Linda Healthcare System · NIH-11413002 · Data updated 2026-11-12
A bone-healing strategy using 3D-printed scaffolds and two small molecules aims to improve fracture healing in a mouse model of chronic kidney disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Loma Linda Healthcare System NIH-funded |
| Lab location | 1 site (Loma Linda, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| NIH project number | 1I01RD002336-01 |
| Project ID | NIH-11413002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be individuals with CKD and bone fractures where enhanced healing could significantly improve outcomes (preclinical stage: animal model findings guiding future human studies).
✕Less likely to help
People without CKD or those with fractures not related to CKD-associated healing impairment may not benefit.
What this research studies
This project tests a treatment that combines a 3D-printed scaffold with two drugs that boost healing signals at the fracture site in CKD-affected mice. It targets IL-17A and Wnt signaling to promote both cartilage and bone formation during healing. The study will compare combination therapy to single-drug approaches to see which promotes better bone repair in a disease-relevant model. Findings could shape future approaches for veterans with CKD-related bone healing problems.
Why it matters
Potential benefit: If successful, this approach could lead to faster and more reliable fracture healing for patients with CKD.
How similar studies have gone: Previous work shows promise for combined signaling pathway approaches in bone healing, but this exact combination in CKD models is novel.
Where this research is happening
-
VA Loma Linda Healthcare System
Loma Linda, United States Active
Researchers
- Principal investigator: Mohan, Subburaman — VA Loma Linda Healthcare System
- Study coordinator: Mohan, Subburaman
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.