Immunomodulation after polytrauma to help bone healing
Official title: Systemic and local immunomodulation of fracture healing in polytrauma
Funded at University of California at Davis · NIH-11374937 · Data updated 2026-11-12
This NIH grant explores how inflammation and immune signals affect bone healing after severe injuries in adults to improve recovery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | July 15, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $169,344 |
| NIH project number | 5K08AR084594-02 |
| Project ID | NIH-11374937 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who have suffered polytrauma with fractures and impaired healing.
✕Less likely to help
Patients without polytrauma-related fractures or those not at risk of impaired healing may not benefit.
What this research studies
The project looks at how multiple injuries influence fracture repair, focusing on immune and inflammatory pathways. Researchers will study how mesenchymal stromal cells respond in a polytrauma setting and how immunomodulatory strategies might support healing. The work combines clinical experience with mechanistic lab studies to identify targets that could improve bone regeneration after major trauma. If successful, findings could guide future therapies that help patients recover faster and regain function after complex injuries.
Why it matters
Potential benefit: Better understanding of immune-related factors could lead to new treatments that improve fracture healing after polytrauma.
How similar studies have gone: Previous work suggests inflammation affects fracture healing, but few studies directly link polytrauma–specific immune modulation to improved bone repair.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Saiz, Augustine — University of California at Davis
- Study coordinator: Saiz, Augustine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.