MAC-STILA: Safer, gentler anesthesia for hip fracture in older adults
Official title: Monitored Anesthesia Care and Soft Tissue Infiltration with Local Anesthesia for Older Adults with Hip Fracture: A Multi-Center Feasibility Randomized Clinical Trial
Funded at New York University School of Medicine · NIH-11399101 · Data updated 2026-11-12
A multi-center trial tests a new anesthesia approach (MAC-STILA) to reduce delirium and other problems after hip-fracture surgery in older adults with dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $649,064 |
| NIH project number | 5R01AG090860-02 |
| Project ID | NIH-11399101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults (likely with dementia or cognitive impairment) undergoing hip fracture surgery who are candidates for MAC-STILA.
✕Less likely to help
Patients who require or strongly prefer general anesthesia or have contraindications to the MAC-STILA approach may not benefit.
What this research studies
Older adults with hip fractures and dementia are at high risk for delirium after surgery. This study tests a combination of monitored IV sedation and local anesthesia at the surgical site to see if it reduces delirium and improves recovery compared with the standard general anesthesia. The trial will recruit 140 patients across six hospitals, with careful planning and consensus-building among surgeons and anesthesiologists to ensure the approach can be reliably used. Participants will be randomized to MAC-STILA or conventional anesthesia, with cognitive status at baseline used to guide analysis.
Why it matters
Potential benefit: If successful, MAC-STILA could lessen delirium and improve recovery after hip surgery for older adults with dementia.
How similar studies have gone: This represents a novel approach that needs feasibility data and early efficacy signals; prior work suggests potential benefits but this exact strategy is unproven.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Konda, Sanjit — New York University School of Medicine
- Study coordinator: Konda, Sanjit
Related research
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This study is looking at how bone strength changes as we age and what factors might help predict the risk of hip fractures in older adults, so we can better understand and prevent these injuries.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.