HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury
Official title: HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial
Funded at University of Maryland Baltimore · NIH-11382759 · Data updated 2026-11-12
A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $530,134 |
| NIH project number | 5U01AR080377-04 |
| Project ID | NIH-11382759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with hip fracture and elevated troponin indicating acute heart injury, treated at participating centers.
✕Less likely to help
Patients without acute heart injury or those not suitable for accelerated surgery may not experience benefit.
What this research studies
This study enrolls adults with hip fractures and elevated troponin, a sign of acute heart injury, to see if performing surgery within 6 hours leads to better 90-day survival, more patients walking independently at 90 days, and improved quality of life. It is a large randomized trial across multiple centers led by the University of Maryland Baltimore. Participants will be randomized to accelerated surgery versus standard timing, with follow-up assessments of mortality, mobility, and patient-reported outcomes.
Why it matters
Potential benefit: If successful, patients with this combination of injuries could experience shorter recovery times and better overall outcomes after hip fracture.
How similar studies have gone: Earlier post-hoc findings suggested potential benefits of faster surgery in this subgroup, justifying a definitive trial.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: O'toole, Robert V. — University of Maryland Baltimore
- Study coordinator: O'toole, Robert V.
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.