NIH-funded research U01 cooperative agreement

HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury

Official title: HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial

Funded at University of Maryland Baltimore · NIH-11382759 · Data updated 2026-11-12

A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.

More Fracture research and trials

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniversity of Maryland Baltimore
NIH-funded
Lab location1 site (Baltimore, United States)
Project startAugust 1, 2022
Project endJuly 31, 2027
Funding year2026
Award (this year)$530,134
NIH project number5U01AR080377-04
Project IDNIH-11382759 on NIH RePORTER

Who could benefit from this research

Could help

Adults with hip fracture and elevated troponin indicating acute heart injury, treated at participating centers.

Less likely to help

Patients without acute heart injury or those not suitable for accelerated surgery may not experience benefit.

What this research studies

This study enrolls adults with hip fractures and elevated troponin, a sign of acute heart injury, to see if performing surgery within 6 hours leads to better 90-day survival, more patients walking independently at 90 days, and improved quality of life. It is a large randomized trial across multiple centers led by the University of Maryland Baltimore. Participants will be randomized to accelerated surgery versus standard timing, with follow-up assessments of mortality, mobility, and patient-reported outcomes.

Why it matters

Potential benefit: If successful, patients with this combination of injuries could experience shorter recovery times and better overall outcomes after hip fracture.

How similar studies have gone: Earlier post-hoc findings suggested potential benefits of faster surgery in this subgroup, justifying a definitive trial.

Where this research is happening

  • University of Maryland Baltimore
    Baltimore, United States
    Active

Researchers

  • Principal investigator: O'toole, Robert V. — University of Maryland Baltimore
  • Study coordinator: O'toole, Robert V.

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.