Hip fracture risk in people with chronic kidney disease
Official title: Hip Fracture Pathology in Chronic Kidney Disease
Funded at University of California, San Diego · NIH-11298380 · Data updated 2026-11-12
A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 1, 2020 |
| Project end | February 28, 2031 |
| Funding year | 2026 |
| Award (this year) | $708,593 |
| NIH project number | 2R01AG065876-06 |
| Project ID | NIH-11298380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease who are at risk for hip fractures and may have abnormal bone turnover.
✕Less likely to help
People without CKD or those not at risk for hip fractures may not benefit.
What this research studies
If you have CKD, you may face a higher risk of hip fractures and related health problems. Researchers will look at bone turnover markers and how they relate to fracture risk, aiming to identify which patients are most at risk and how to tailor prevention. The project builds on prior findings that bone turnover varies by site and that low turnover is common, which can affect which treatments are safest. By connecting biomarkers, neuropathy, and bone health, the study hopes to guide personalized prevention strategies. This work is led by UC San Diego and aims to reduce hip fracture impact for CKD patients.
Why it matters
Potential benefit: If successful, the study could lead to better, personalized strategies to prevent hip fractures in CKD patients.
How similar studies have gone: Prior work showed bone turnover markers can identify high-risk CKD patients and distinguish hip vs iliac crest turnover differences.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hughes-Austin, Jan Marie — University of California, San Diego
- Study coordinator: Hughes-Austin, Jan Marie
Related research
Other NIH-funded projects on the same topics.
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Understanding hip fractures in patients with chronic kidney disease
This study is looking at the special challenges faced by people with chronic kidney disease who have hip fractures, to better understand their bone health and help doctors find the best treatments for them.
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Therapeutic use of 3D-printed scaffolds and small-molecule activators to heal bone fractures in CKD mice
A bone-healing strategy using 3D-printed scaffolds and two small molecules aims to improve fracture healing in a mouse model of chronic kidney disease.
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Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
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Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.