Improving bone healing in obese individuals
Official title: Targeting Unfolded Protein Response (UPR) to improve fracture repair in obesity
Funded at Texas A&m Agrilife Research · NIH-11293189 · Data updated 2026-11-12
This study is looking at how being overweight affects the healing of broken bones, especially for people with diabetes, and it hopes to find ways to help improve recovery for those who struggle with this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | December 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $406,684 |
| NIH project number | 7R01AR083711-03 |
| Project ID | NIH-11293189 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals who have experienced bone fractures, particularly those with diabetes or related complications.
✕Less likely to help
Patients who are not obese or do not have a history of bone fractures may not benefit from this research.
What this research studies
This research investigates how obesity affects the healing of bone fractures, particularly focusing on the role of the Unfolded Protein Response (UPR) in this process. It aims to understand the mechanisms behind poor fracture outcomes in obese patients, especially those with diabetes, by examining how the UPR influences protein synthesis and bone cell function during healing. The study will explore the relationship between obesity, cellular stress, and the ability of bone cells to repair fractures effectively. By identifying these mechanisms, the research seeks to develop targeted interventions to enhance fracture repair in obese individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone fractures in obese patients, reducing recovery time and associated medical costs.
How similar studies have gone: Previous studies have shown that targeting cellular stress responses can improve healing outcomes in various conditions, suggesting potential success for this approach.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Iyer, Srividhya — Texas A&m Agrilife Research
- Study coordinator: Iyer, Srividhya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.