Modulation of Bone Formation and Fracture Repair in Cancer Patients
Official title: Modulation of Bone Formation and Fracture Repair During Cancer Development
Funded at Washington University · NIH-11297367 · Data updated 2026-11-12
This grant aims to understand how cancer and its treatments affect bone formation and fracture healing, with the goal of improving bone health for cancer survivors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 22, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $577,398 |
| NIH project number | 1R01AR085668-01A1 |
| Project ID | NIH-11297367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) with breast cancer or cancer history, and individuals at risk for bone complications from cancer therapies.
✕Less likely to help
Patients without cancer or bone-related complications may not directly benefit.
What this research studies
Cancer survivors, especially those with breast cancer, often face bone loss and weaker fracture repair. The project looks at how primary breast cancer and its therapies impact osteoprogenitor cells and bone formation, using human-focused approaches and ATAC-seq to study chromatin changes. If successful, findings could point to new ways to protect or restore bone in people living with cancer. The work builds on animal data and seeks to translate insights into strategies that support healthier bones during and after cancer treatment.
Why it matters
Potential benefit: Potentially better bone health and fracture healing for cancer patients and survivors.
How similar studies have gone: Previous data in mice suggest a link between cancer progression and impaired bone formation, guiding a promising translational path.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Faccio, Roberta — Washington University
- Study coordinator: Faccio, Roberta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.