Boosting bone metabolism to speed fracture healing in diabetes
Official title: NAMPT regulation of fracture tissue metabolism during bone healing
Funded at VA Loma Linda Healthcare System · NIH-11415402 · Data updated 2026-11-12
Seeing if raising a molecule called NAMPT in broken bones helps people with obesity-related type 2 diabetes heal fractures faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Loma Linda Healthcare System NIH-funded |
| Lab location | 1 site (Loma Linda, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2026 |
| NIH project number | 5I21RX004395-03 |
| Project ID | NIH-11415402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obesity-related type 2 diabetes who have a recent bone fracture or delayed fracture healing would be the most relevant future candidates.
✕Less likely to help
People without type 2 diabetes, children, or those with fractures caused by very different processes may not benefit from this specific metabolic approach.
What this research studies
This work uses mice that have obesity and type 2 diabetes to model the slow bone healing many patients experience. Researchers will screen drugs that activate NAMPT in bone-forming cells and pick the most promising candidates. Those candidates will be applied directly to fracture sites in the diabetic mice to see if local boosting of NAMPT improves healing. Findings could point to treatments that target the metabolism of fracture tissue to help people with diabetes recover better from broken bones.
Why it matters
Potential benefit: If successful, this could lead to new treatments that speed fracture healing and lower complication risks for people with obesity-related type 2 diabetes.
How similar studies have gone: Animal studies boosting NAD-related pathways have shown improved tissue repair, but directly applying NAMPT activators to fractures in diabetic models is a newer, less-tested approach.
Where this research is happening
-
VA Loma Linda Healthcare System
Loma Linda, United States Active
Researchers
- Principal investigator: Rundle, Charles — VA Loma Linda Healthcare System
- Study coordinator: Rundle, Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.