Local adenosine treatment to reduce pain and help heal bone fractures
Modulation of local adenosine signaling to attenuate fracture pain
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11303603
This work is developing a local adenosine-based approach to relieve pain and support healing for people with bone fractures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11303603 on ClinicalTrials.gov |
What this research studies
The team is creating an injectable biomaterial that releases adenosine directly at a broken bone to both blunt pain signals and encourage bone formation. They will test different doses and formulations in lab and preclinical models to see how the material affects pain and fracture healing. Measurements will include pain-related outcomes and markers of bone repair over time, alongside safety checks for the delivery material. If promising, the approach would be prepared for future clinical testing in patients with fractures.
Who could benefit from this research
Good fit: People with recent acute bone fractures or recovering from orthopedic fracture surgery who need pain relief and want alternatives to NSAIDs or opioids.
Not a fit: People with chronic non-fracture pain conditions or pain unrelated to bone injury are unlikely to benefit from this fracture-focused approach.
Why it matters
Potential benefit: If successful, this approach could lessen fracture pain while improving bone healing and reduce reliance on NSAIDs or opioids.
How similar studies have performed: Prior laboratory and animal studies show adenosine can promote bone growth and reduce pain, but using a local injectable biomaterial for fractures is relatively new.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VARGHESE, SHYNI — DUKE UNIVERSITY
- Study coordinator: VARGHESE, SHYNI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.