Intermittent Fasting to Boost Fracture Healing in Obesity and Type 2 Diabetes

Who could benefit from this research

What this research studies

This project uses a obesity/diabetes mouse model to see how intermittent fasting affects bone repair after fracture, focusing on inflammatory and repair-phase processes and the cells that form bone. Researchers will look at how feeding patterns alter the callus and its gene activity, and whether probiotics can mimic the benefits seen with fasting. They will also test whether blood plasma from people practicing intermittent fasting can influence human bone marrow cells in the lab. The goal is to identify mechanisms by which the gut microbiome supports bone healing and to translate findings toward human treatment strategies.

Why it matters

Where this research is happening

• University of Colorado Denver
  Aurora, United States Active

Researchers

• Principal investigator: Hendesi, Honey — University of Colorado Denver
• Study coordinator: Hendesi, Honey

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.