Non-invasive tool to predict fatty liver disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a clinical scoring tool that can accurately predict metabolic dysfunction-associated steatotic liver disease (MASLD) in volunteers without the need for invasive tests like biopsies. The study will recruit 2000 participants, including both healthy individuals and those with known MASLD, who will undergo a series of assessments in a single visit. These assessments include blood tests, body measurements, bioimpedance analysis, and liver imaging techniques. The goal is to establish a reliable screening method that can identify fatty liver disease early, potentially improving patient outcomes in clinical settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female volunteers aged ≥18 to ≤80 years at the date of signing the informed consent.
2. Willingness and ability to provide written, personally signed, and dated informed consent, in accordance with the latest ICH Good Clinical Practice (GCP) Guidelines and applicable regulations.
3. An understanding, ability and willingness to fully comply with project procedures and restrictions.

For PART B only:

1\. With a known history of MASLD as evidenced either of:

1. GP diagnosis on HCF
2. Documented Fibroscan or liver US demonstrating MASLD

Exclusion Criteria:

1. Known alcoholic liver disease, history of cirrhosis of any other cause (metabolic, viral hepatitis or other)
2. Any other significant previous liver pathology (liver malignancy, portal hypertension, infiltrative liver disease)
3. Alcohol consumption \>30 units per week
4. An Implanted cardiac devices

Where it's running

• Richmond Pharmacology Ltd. 1a Newcomen St, London Bridge
  London, London, United Kingdom Recruiting

Study contacts

• Principal investigator: Jorg Taubel, MD — Richmond Pharmacology Limited
• Study coordinator: James Rickard
• Email: grants@richmondresearchinstitute.org
• Phone: +44 (0)20 7042 5800

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Peanut intake and liver health in adults with MASLD

  This study tests whether adding peanuts to daily meals for 12 weeks can improve liver markers and metabolic health in adults with MASLD.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT07646197

• Low‑methoxy pectin for inflammation, gut microbiome, and metabolic health in MASLD

  This tests whether taking daily low‑methoxy pectin for six weeks can reduce inflammation and improve gut bacteria and metabolic markers in adults with MASLD.

  Recruiting at 3 sites University of Nottingham · Nottingham, United Kingdom and 2 other locations · NCT07093346

• Using advanced ultrasound to evaluate liver disease in children

  This study is testing new ultrasound methods to see if they can help doctors better detect and monitor liver fat in children at risk for liver disease.

  Recruiting University of California, San Diego · La Jolla, California · NCT06706856

• Ultraportable Hepatoscope ultrasound for measuring liver fat in MASLD/MASH

  The Hepatoscope device will be tested to see if it can measure liver fat accurately in adults with MASLD/MASH compared with MRI-PDFF.

  Recruiting at 2 sites E-Scopics · Angers and 2 other locations · NCT06661655

• Investigating heart problems in patients with fatty liver disease

  This study looks at how fatty liver disease might affect heart health in adults aged 18-65 by checking for heart problems like coronary artery disease and heart failure.

  Recruiting Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh, Chandigarh · NCT06386094

• Reset-INSPIRE: See if CGM can reveal insulin sensitivity in people at risk for MASLD

  This study tests whether real-time CGM data can accurately reflect insulin sensitivity in adults without diabetes who are at risk for MASLD.

  Recruiting National University Health System, Singapore · Singapore, Singapore · NCT07861191

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.