Analyzing ELF Test for Early Detection of Fatty Liver in High-Risk Patients
Official title: Exploratory Analysis of Enhanced Liver Function (ELF) Test to Detect Early Fatty Liver in High Risk Population
Run by Methodist Health System · NCT06225193 · Data updated 2026-11-12
This study is testing if a new liver test can help find early signs of fatty liver disease in people at high risk, like those with metabolic syndrome, and see how lifestyle changes or medications affect their liver health over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Methodist Health System Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Status | Recruiting |
| Started | June 20, 2023 |
| Main results expected | June 23, 2026 |
| Study ends | June 23, 2026 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT06225193 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with risk factors for NAFLD/NASH who have undergone ELF score assessment at Methodist Dallas Medical Center.
✕Probably not a fit
Patients with incomplete data or those lost to follow-up will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to analyze enhanced liver fibrosis (ELF) scores in a high-risk population for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The study focuses on patients with metabolic syndrome and other risk factors, comparing ELF scores with traditional fibrosis assessment methods. It will also evaluate the impact of lifestyle changes and pharmacotherapy on ELF scores over time. The goal is to provide a non-invasive and cost-effective means of detecting liver fibrosis and predicting liver-related events in primary care settings.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and better management of fatty liver disease in high-risk patients.
How similar studies have gone: While the ELF test is a newer approach, similar studies have shown promise in using non-invasive methods for liver fibrosis assessment.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: ≥ 18 years * NAFLD/NASH and non-NAFLD/NASH patients who have had an assessment with ELF score at Methodist Dallas Medical Center from November 2021 to December 2023. Exclusion Criteria: * Patients with incomplete data and those lost to follow up.
Where it's running
-
Methodist Dallas Medical Center
Dallas, Texas, United States Recruiting
Study contacts
- Principal investigator: Parvez Mantry, MD — Methodist Midlothian Medical Center
- Study coordinator: Crystee Cooper
- Email: crysteecooper@mhd.com
- Phone: 2149471280
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Metabolic Liver Disease in People Newly Diagnosed with HIV
This study tests whether HIV-infected adults who are starting ART are more likely to develop MASLD and related liver issues than HIV-negative adults over five years.
-
Peanut intake and liver health in adults with MASLD
This study tests whether adding peanuts to daily meals for 12 weeks can improve liver markers and metabolic health in adults with MASLD.
-
Photon-counting CT and ultrasound for detecting liver fat and scarring
This will test whether a new photon-counting CT plus ultrasound can find liver fat and scarring in adults with fatty liver or liver fibrosis, using MRI as the reference.
-
Erdosteine for nonalcoholic fatty liver disease
This trial will try erdosteine alongside standard therapy in adults with nonalcoholic fatty liver disease confirmed by ultrasound to see if it improves liver fat and liver health.
-
Cilostazol for nonalcoholic fatty liver disease.
This trial will test whether the medicine cilostazol can reduce liver fat and improve liver health in adults with nonalcoholic fatty liver disease.
-
Gepaktiv compared with UDCA and Ademetionine for MAFLD with enlarged liver
This study will try the dietary supplement Gepaktiv to see if it improves liver enzymes, liver size, and fat in adults with MAFLD and hepatomegaly compared with UDCA and ademetionine.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.