Investigating how lipid droplet proteins affect liver disease and inflammation
The role of lipid droplet proteins in eicosanoid production and non-alcoholic fatty liver disease
This study is looking at how certain proteins in fat droplets affect the way our bodies handle fats and how this relates to non-alcoholic fatty liver disease (NAFLD), and it may involve patients helping to find out if their genes play a role in their liver health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11162453 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of lipid droplet proteins in the metabolism of fatty acids and their impact on non-alcoholic fatty liver disease (NAFLD). The study will explore how genetic variations in specific lipid droplet proteins influence the production of eicosanoids, which are signaling molecules involved in inflammation and liver health. By analyzing these proteins and their effects on fatty acid metabolism, the research aims to uncover new insights into the progression of NAFLD and its associated risks. Patients may be involved in genetic assessments to identify variations that could affect their liver health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with non-alcoholic fatty liver disease or those at risk due to genetic factors.
Not a fit: Patients without non-alcoholic fatty liver disease or those who do not have the relevant genetic variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of non-alcoholic fatty liver disease, potentially reducing associated health risks.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism and its implications for liver disease, indicating that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Scorletti, Eleonora — University of Pennsylvania
- Study coordinator: Scorletti, Eleonora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.