Comparing cost-effective ways to prevent liver cancer in MAFLD
Official title: Comparative cost-effectiveness of HCC prevention in metabolic dysfunction associated fatty liver disease
Funded at Baylor College of Medicine · NIH-11379132 · Data updated 2026-11-12
This grant looks at which prevention strategies for liver cancer in people with MAFLD give the best value for patients and the health system.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $276,775 |
| NIH project number | 5P01CA263025-05 |
| Project ID | NIH-11379132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with MAFLD who are at risk for HCC and may be candidates for prevention strategies.
✕Less likely to help
Individuals without MAFLD or those not at elevated HCC risk may not benefit from these prevention strategies.
What this research studies
Hepatocellular carcinoma is rapidly increasing and MAFLD is a major driver. The project aims to compare the cost-effectiveness of different prevention approaches, including surveillance and chemoprevention, in adults with MAFLD. It builds on existing evidence gaps and uses data to inform which strategies could most reduce mortality and burden. The work involves health-economic analyses to guide clinical and policy decisions that could affect patient care in the future.
Why it matters
Potential benefit: If successful, the study could help clinicians and policymakers choose prevention strategies that save lives and reduce costs for patients with MAFLD.
How similar studies have gone: Previous work in cancer prevention shows value in cost-effectiveness analyses, but this project focuses on MAFLD-related HCC prevention, extending prior findings.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Chhatwal, Jagpreet — Baylor College of Medicine
- Study coordinator: Chhatwal, Jagpreet
Related research
Other NIH-funded projects on the same topics.
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Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
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Researchers are looking at whether changes in the TET1 gene and DNA 'tagging' (methylation) play a role in adult non-alcoholic fatty liver disease.
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A large NIH grant helps researchers study why fatty liver develops in Hispanic adults and how genetics interact with lifestyle to affect risk.
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Glutamine and T cells in fatty liver disease
A study explores how liver glutamine levels affect inflammatory CD4+ T cells in fatty liver disease to find potential new ways to reduce liver inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.