Impact of Cardiac Rehabilitation on DNA Damage and Inflammation in Heart Disease Patients
Official title: The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients With Coronary Artery Disease
Run by TC Erciyes University · NCT06867926 · Data updated 2026-11-12
This study is testing if cardiac rehabilitation can reduce DNA damage and inflammation in people with coronary artery disease to help improve their heart health.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | TC Erciyes University Academic / other |
| Locations | 1 site (Kayseri) |
| Status | Recruiting |
| Started | May 15, 2025 |
| Main results expected | July 1, 2025 |
| Study ends | December 1, 2025 |
| Registry record updated | May 2, 2025 |
| Trial ID | NCT06867926 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18-65 with a diagnosis of coronary artery disease who can safely participate in cardiac rehabilitation.
✕Probably not a fit
Patients with heart failure, unstable angina, or other serious health conditions that contraindicate exercise may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effects of cardiac rehabilitation on oxidative DNA damage and inflammation in patients diagnosed with coronary artery disease (CAD). It measures levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an indicator of oxidative stress and assesses proinflammatory cytokines such as TNFα, IL-1β, and IL-6. The study seeks to understand the relationship between these markers and the benefits of cardiac rehabilitation, which combines medical and exercise interventions to enhance cardiovascular health. Participants will undergo cardiopulmonary exercise testing to ensure eligibility for the rehabilitation program.
Why it matters
Potential benefit: If successful, this study could provide insights into how cardiac rehabilitation may reduce oxidative stress and inflammation, potentially improving outcomes for patients with coronary artery disease.
How similar studies have gone: Previous studies have shown promising results regarding the benefits of cardiac rehabilitation on cardiovascular health, suggesting that this approach may be effective in managing oxidative stress and inflammation in CAD patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion Criteria for Patient Volunteers 1. Patients aged 18-65 years with a diagnosis of coronary artery disease and no contraindications to cardiac rehabilitation and exercise testing 2. Patients who will undergo cardiopulmonary exercise testing before cardiac rehabilitation 3. Patients whose cognitive status is sufficient to complete the study and who can cooperate Inclusion Criteria for Healthy Volunteers 1. 18 years of age or older 2. Not having a chronic disease (such as uncontrolled diabetes mellitus, hypertension, heart and kidney failure) 3. Not taking regular medication Exclusion Criteria: Exclusion Criteria for Patient Volunteers 1. Having heart failure 2. Unstable Angina Pectoris 3. Complex ventricular arrhythmia 4. Having a pacemaker 5. Having orthopedic or neurological diseases that prevent exercise 6. Having kidney-liver disease 7. Exercise is contraindicated 8. History of inflammatory diseases 9. Having a history of cancer-immunologic disease Exclusion Criteria for Healthy Volunteers 1. Having a history of chronic diseases such as diabetes mellitus, hypertension, heart and kidney failure 2. Being on regular medication for the last 6 months 3. being under 18 years of age
Where it's running
-
Erciyes University Faculty of Medicine
Kayseri, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Hasan KARA, M.D.
- Email: drhasankara@yandex.com
- Phone: +905552592665
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.